Effects of ospemifene and raloxifene on hormonal status, lipids, genital tract and tolerability in postmenopausal women

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Komi, J (author)

Effects of ospemifene and raloxifene on hormonal status, lipids, genital tract and tolerability in postmenopausal women

Article/chapterEnglish2005

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2005

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LIBRIS-ID:oai:lup.lub.lu.se:f09980c6-183b-4431-b491-1bd095d3a151
https://lup.lub.lu.se/record/1133683URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

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OBJECTIVE: To compare ospemifene and raloxifene regarding their effects on hormones, lipids, genital tract, and tolerability in postmenopausal women. DESIGN: A randomized, double-blind study in which 118 healthy postmenopausal women received 30 (n = 29), 60 (n = 30), or 90 mg (n = 30) of ospemifene or 60 mg (n = 29) of raloxifene for 3 months. RESULTS: There were no significant differences in the baseline characteristics between study groups. In comparison with raloxifene, follicle-stimulating hormone levels decreased significantly more in the 90-mg ospemifene group and sex hormone-binding globulin levels increased more in all ospemifene groups. Total cholesterol and low-density lipoprotein cholesterol levels decreased more in raloxifene than in ospemifene groups, although the difference in low-density lipoprotein cholesterol between 90-mg ospemifene and raloxifene was not significant. Endometrial thickness did not change in any study group and endometrial biopsies showed atrophy in the majority of subjects at 3 months. All ospemifene groups demonstrated a clear estrogenic effect on the vaginal epithelium, as seen in Pap smears. This was in sharp contrast to the raloxifene group, which had no effect on the vaginal epithelium. Kupperman index decreased in all study groups during treatment. The adverse events were mild, mainly single cases, and no clustering of events was observed. There were no clinically significant abnormal findings in laboratory safety parameters. CONCLUSIONS: Ospemifene, at the dose of 90 mg/day, was more estrogenic than raloxifene, as shown by changes in serum follicle-stimulating hormone and sex hormone-binding globulin levels. Neither agent stimulated endometrium, but in contrast to raloxifene, ospemifene had a clear estrogenic effect in the vagina. Further studies with ospemifene are needed in subjects with vaginal atrophy.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
Selective estrogen receptor modulators
Ospemifene
Raloxifene
Postmenopausal
Vaginal atrophy

Added entries (persons, corporate bodies, meetings, titles ...)

Lankinen, K S (author)
Härkönen, PirkkoLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine(Swepub:lu)klke-ph0 (author)
DeGregorio, M W (author)
Voipio, S (author)
Kivinen, S (author)
Tuimala, R (author)
Vihtamaki, T (author)
Vihko, K (author)
Ylikorkala, O (author)
Erkkola, R (author)
Institutionen för translationell medicinMedicinska fakulteten (creator_code:org_t)

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In:Menopause12:2, s. 202-2091530-0374

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By the author/editor: Komi, J; Lankinen, K S; Härkönen, Pirkko; DeGregorio, M W; Voipio, S; Kivinen, S; show more...; Tuimala, R; Vihtamaki, T; Vihko, K; Ylikorkala, O; Erkkola, R; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

Articles in the publication: Menopause

By the university: Lund University

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