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IgE sensitization in a cohort of adolescents in southern Sweden and its relation to allergic symptoms
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- Sterner, Therese (author)
- Lund University,Lunds universitet,Dermatologi,Forskargrupper vid Lunds universitet,Dermatology,Lund University Research Groups,Region Skåne,Skåne University Hospital
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- Uldahl, Ada (author)
- Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital
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- Svensson, Åke (author)
- Skåne University Hospital
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- Sjölander, Sigrid (author)
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- (creator_code:org_t)
- 2019-04-02
- 2019
- English.
- In: Clinical and Molecular Allergy. - : Springer Science and Business Media LLC. - 1476-7961. ; 17
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Background: There is a strong and consistent association between IgE sensitization and allergy, wheeze, eczema and food hypersensitivity. These conditions are also found in non-sensitized humans, and sensitization is found among individuals without allergy-related diseases. The aim of this study was to analyse the sensitization profile in a representative sample of the population, and to relate patterns of allergens and allergen components to allergic symptoms. Methods: A population of 195 adolescents took part in this clinical study, which included a self-reported questionnaire and in vitro IgE testing. Results: Sensitization to airborne allergens was significantly more common than sensitization to food allergens, 43% vs. 14%, respectively. IgE response was significantly higher in airborne allergens among adolescents with rhinitis (p < 0.001) and eczema (p < 0.01). Among 53 children with allergic symptoms according to the questionnaire, 60% were sensitized. Sensitization to food allergens was found among those with rhinitis, but only to PR-10 proteins. None of the participants had IgE to seed storage proteins. Conclusion: The adolescents in this study, taken from a normal Swedish population, were mainly sensitized to grass pollen and rarely to specific food allergens. The major grass pollen allergen Phl p 1 was the main sensitizer, followed by Cyn d 1 and Phl p 2. Sixty-one percent reporting any allergic symptom were sensitized, and the allergen components associated with wheeze and rhinoconjunctivitis were Fel d 4, Der f 2 and Can f 5.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Adolescent
- Allergen components
- Allergy
- Asthma
Publication and Content Type
- art (subject category)
- ref (subject category)
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