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IgE sensitization i...
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Sterner, ThereseLund University,Lunds universitet,Dermatologi,Forskargrupper vid Lunds universitet,Dermatology,Lund University Research Groups,Region Skåne,Skåne University Hospital
(author)
IgE sensitization in a cohort of adolescents in southern Sweden and its relation to allergic symptoms
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-04-02
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Springer Science and Business Media LLC,2019
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:f0c13555-60e6-48a7-873f-753753dcb74a
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https://lup.lub.lu.se/record/f0c13555-60e6-48a7-873f-753753dcb74aURI
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https://doi.org/10.1186/s12948-019-0110-6DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Background: There is a strong and consistent association between IgE sensitization and allergy, wheeze, eczema and food hypersensitivity. These conditions are also found in non-sensitized humans, and sensitization is found among individuals without allergy-related diseases. The aim of this study was to analyse the sensitization profile in a representative sample of the population, and to relate patterns of allergens and allergen components to allergic symptoms. Methods: A population of 195 adolescents took part in this clinical study, which included a self-reported questionnaire and in vitro IgE testing. Results: Sensitization to airborne allergens was significantly more common than sensitization to food allergens, 43% vs. 14%, respectively. IgE response was significantly higher in airborne allergens among adolescents with rhinitis (p < 0.001) and eczema (p < 0.01). Among 53 children with allergic symptoms according to the questionnaire, 60% were sensitized. Sensitization to food allergens was found among those with rhinitis, but only to PR-10 proteins. None of the participants had IgE to seed storage proteins. Conclusion: The adolescents in this study, taken from a normal Swedish population, were mainly sensitized to grass pollen and rarely to specific food allergens. The major grass pollen allergen Phl p 1 was the main sensitizer, followed by Cyn d 1 and Phl p 2. Sixty-one percent reporting any allergic symptom were sensitized, and the allergen components associated with wheeze and rhinoconjunctivitis were Fel d 4, Der f 2 and Can f 5.
Subject headings and genre
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Uldahl, AdaLund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-aui
(author)
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Svensson, ÅkeSkåne University Hospital(Swepub:lu)derm-asv
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Borres, Magnus P.Uppsala University
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Sjölander, Sigrid
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Tunsäter, AlfLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Region Skåne(Swepub:lu)med-atr
(author)
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Björk, JonasLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)ymed-jbj
(author)
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Svedman, CeciliaLund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)derm-csv
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Bruze, MagnusSkåne University Hospital(Swepub:lu)derm-mbr
(author)
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Von Kobyletzki, LauraLund University,Lunds universitet,Dermatologi,Forskargrupper vid Lunds universitet,Dermatology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)la7747vo
(author)
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Kiotseridis, HampusLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)pedi-hki
(author)
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DermatologiForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Clinical and Molecular Allergy: Springer Science and Business Media LLC171476-7961
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