Search: onr:"swepub:oai:lup.lub.lu.se:f0c2b346-a12a-47f0-827f-2c468074e178" > Adult-onset type 1 ...
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000 | 04603naa a2200529 4500 | |
001 | oai:lup.lub.lu.se:f0c2b346-a12a-47f0-827f-2c468074e178 | |
003 | SwePub | |
008 | 200717s2021 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/f0c2b346-a12a-47f0-827f-2c468074e1782 URI |
024 | 7 | a https://doi.org/10.1002/dmrr.33572 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Ren, Wenqianu Third Affiliated Hospital of Sun Yat‐sen University4 aut |
245 | 1 0 | a Adult-onset type 1 diabetic patients with less severe clinical manifestation have less risk DR-DQ genotypes than childhood-onset patients |
264 | c 2020-06-21 | |
264 | 1 | b Wiley,c 2021 |
520 | a Background: The aim of this study was to investigate differences in clinical features and HLA genotypes between adult-onset and childhood-onset patients with type 1 diabetes in a Chinese population. Materials and Methods: This study enrolled 716 Han Chinese patients with type 1 diabetes from Guangdong (258 childhood-onset and 458 adult-onset) to compare their clinical features. Of them 214 patients with classical type 1 diabetes (100 childhood-onset and 114 adult-onset) were selected for HLA DR and DQ genotyping by next-generation sequencing. Results: Adult-onset patients were characterized by longer duration of symptoms before diagnosis, lower frequency of DKA at disease onset, less frequent autoantibody positivity, higher serum C-peptide concentrations, and better glycemic control. These findings were replicated in the restricted cohort of 214 patients with classical type 1 diabetes. Compared with childhood-onset patients, adult-onset patients had a lower frequency of the DR9 haplotype, as well as lower frequency of high-risk DR3/DR4 and DR3/DR9 genotypes, but higher frequency of DR3/DR3 genotype and DR3/X, DR4/X or DR9/X (X, non-risk) genotypes. Conclusions: Adult-onset type 1 diabetic patients with susceptible haplotypes (DR3, DR4 or DR9) were more likely to carry protective DR-DQ haplotypes than childhood-onset patients, which suggested the association between less risk DR-DQ genotypes and the less severe clinical manifestation in adult-onset patients. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
653 | a adult onset diabetes | |
653 | a age of diabetes onset | |
653 | a clinical characteristics | |
653 | a genetics | |
653 | a HLA typing | |
653 | a type 1 diabetes | |
700 | 1 | a Yang, Daizhiu Third Affiliated Hospital of Sun Yat‐sen University4 aut |
700 | 1 | a Jiang, Ziyuu Third Affiliated Hospital of Sun Yat‐sen University4 aut |
700 | 1 | a Xian, Yingxinu Third Affiliated Hospital of Sun Yat‐sen University4 aut |
700 | 1 | a Huang, Qianwenu Third Affiliated Hospital of Sun Yat‐sen University4 aut |
700 | 1 | a Luo, Sihuiu University of Science and Technology of China,Third Affiliated Hospital of Sun Yat‐sen University4 aut |
700 | 1 | a Zheng, Xueyingu University of Science and Technology of China4 aut |
700 | 1 | a Yan, Jinhuau Third Affiliated Hospital of Sun Yat‐sen University4 aut |
700 | 1 | a Xu, Wenu Third Affiliated Hospital of Sun Yat‐sen University4 aut |
700 | 1 | a Yao, Binu Third Affiliated Hospital of Sun Yat‐sen University4 aut |
700 | 1 | a Wang, Cong Yiu Huazhong University of Science and Technology4 aut |
700 | 1 | a Bei, Jin Xinu Sun Yat-sen University4 aut |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Science and Technology of China,Skåne University Hospital4 aut0 (Swepub:lu)endo-lgr |
700 | 1 | a Noble, Janelle A.u Children's Hospital Oakland Research Institute4 aut |
700 | 1 | a Weng, Jianpingu University of Science and Technology of China,Third Affiliated Hospital of Sun Yat‐sen University4 aut |
710 | 2 | a Third Affiliated Hospital of Sun Yat‐sen Universityb University of Science and Technology of China4 org |
773 | 0 | t Diabetes/Metabolism Research and Reviewsd : Wileyg 37:1q 37:1x 1520-7552x 1520-7560 |
856 | 4 | u http://dx.doi.org/10.1002/dmrr.3357x freey FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/f0c2b346-a12a-47f0-827f-2c468074e178 |
856 | 4 8 | u https://doi.org/10.1002/dmrr.3357 |
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