Search: onr:"swepub:oai:lup.lub.lu.se:f1380a92-6013-46f9-8f86-927342afca3b" > Genome-Wide Polygen...
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000 | 04382naa a2200469 4500 | |
001 | oai:lup.lub.lu.se:f1380a92-6013-46f9-8f86-927342afca3b | |
003 | SwePub | |
008 | 201105s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/f1380a92-6013-46f9-8f86-927342afca3b2 URI |
024 | 7 | a https://doi.org/10.1161/ATVBAHA.120.3148562 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Hindy, Georgeu Qatar University4 aut0 (Swepub:lu)med-ghu |
245 | 1 0 | a Genome-Wide Polygenic Score, Clinical Risk Factors, and Long-Term Trajectories of Coronary Artery Disease |
264 | 1 | c 2020 |
300 | a 9 s. | |
520 | a OBJECTIVE: To determine the relationship of a genome-wide polygenic score for coronary artery disease (GPSCAD) with lifetime trajectories of CAD risk, directly compare its predictive capacity to traditional risk factors, and assess its interplay with the Pooled Cohort Equations (PCE) clinical risk estimator. Approach and Results: We studied GPSCAD in 28 556 middle-aged participants of the Malmö Diet and Cancer Study, of whom 4122 (14.4%) developed CAD over a median follow-up of 21.3 years. A pronounced gradient in lifetime risk of CAD was observed-16% for those in the lowest GPSCAD decile to 48% in the highest. We evaluated the discriminative capacity of the GPSCAD-as assessed by change in the C-statistic from a baseline model including age and sex-among 5685 individuals with PCE risk estimates available. The increment for the GPSCAD (+0.045, P<0.001) was higher than for any of 11 traditional risk factors (range +0.007 to +0.032). Minimal correlation was observed between GPSCAD and 10-year risk defined by the PCE (r=0.03), and addition of GPSCAD improved the C-statistic of the PCE model by 0.026. A significant gradient in lifetime risk was observed for the GPSCAD, even among individuals within a given PCE clinical risk stratum. We replicated key findings-noting strikingly consistent results-in 325 003 participants of the UK Biobank. CONCLUSIONS: GPSCAD-a risk estimator available from birth-stratifies individuals into varying trajectories of clinical risk for CAD. Implementation of GPSCAD may enable identification of high-risk individuals early in life, decades in advance of manifest risk factors or disease. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a coronary artery disease | |
653 | a disease | |
653 | a genome | |
653 | a risk factors | |
653 | a statistics | |
700 | 1 | a Aragam, Krishna G.u Harvard University,Broad Institute,Massachusetts General Hospital4 aut |
700 | 1 | a Ng, Kenneyu IBM Research Cambridge4 aut |
700 | 1 | a Chaffin, Marku Broad Institute4 aut |
700 | 1 | a Lotta, Luca A.u Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Baras, Arisu Regeneron Pharmaceuticals, Inc.4 aut |
700 | 1 | a Drake, Isabelu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)med-ihm |
700 | 1 | a Orho-Melander, Marjuu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome |
700 | 1 | a Kathiresan, Sekaru Massachusetts General Hospital,Broad Institute,Harvard University4 aut |
700 | 1 | a Khera, Amit V.u Harvard University,Broad Institute,Massachusetts General Hospital4 aut |
710 | 2 | a Qatar Universityb Harvard University4 org |
773 | 0 | t Arteriosclerosis, Thrombosis, and Vascular Biologyg 40:11, s. 2738-2746q 40:11<2738-2746x 1524-4636 |
856 | 4 | u http://dx.doi.org/10.1161/ATVBAHA.120.314856x freey FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/f1380a92-6013-46f9-8f86-927342afca3b |
856 | 4 8 | u https://doi.org/10.1161/ATVBAHA.120.314856 |
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