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Animal Models of Me...
Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases : An Overview
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- de Bem, Andreza Fabro (author)
- University of Brasilia
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- Krolow, Rachel (author)
- Federal University of Rio Grande do Sul
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- Farias, Hémelin Resende (author)
- Federal University of Rio Grande do Sul
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- de Rezende, Victória Linden (author)
- Federal University of Rio Grande do Sul
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- Gelain, Daniel Pens (author)
- Federal University of Rio Grande do Sul
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- Moreira, José Cláudio Fonseca (author)
- Federal University of Rio Grande do Sul
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- Duarte, João Miguel das Neves (author)
- Lund University,Lunds universitet,Diabetes och hjärnans funktion,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Diabetes and Brain Function,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine
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- de Oliveira, Jade (author)
- Federal University of Rio Grande do Sul
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(creator_code:org_t)
- 2021-01-18
- 2021
- English.
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In: Frontiers in Neuroscience. - : Frontiers Media SA. - 1662-4548 .- 1662-453X. ; 14
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Abstract
Subject headings
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- The incidence of metabolic disorders, as well as of neurodegenerative diseases—mainly the sporadic forms of Alzheimer’s and Parkinson’s disease—are increasing worldwide. Notably, obesity, diabetes, and hypercholesterolemia have been indicated as early risk factors for sporadic forms of Alzheimer’s and Parkinson’s disease. These conditions share a range of molecular and cellular features, including protein aggregation, oxidative stress, neuroinflammation, and blood-brain barrier dysfunction, all of which contribute to neuronal death and cognitive impairment. Rodent models of obesity, diabetes, and hypercholesterolemia exhibit all the hallmarks of these degenerative diseases, and represent an interesting approach to the study of the phenotypic features and pathogenic mechanisms of neurodegenerative disorders. We review the main pathological aspects of Alzheimer’s and Parkinson’s disease as summarized in rodent models of obesity, diabetes, and hypercholesterolemia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer’s disease
- diabetes
- hypercholesterolemia
- neurodegeneration
- obesity
- Parkinson’s disease
- rodent models
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