NSAID visar övertygande effekt vid postoperativ smärta

• Non-steroidal antiinflammatory drugs (NSAID) are increasingly being included in the management of postoperative pain as part of a multimodal therapeutic approach. However, there is an ongoing debate among clinicians as to the perioperative use of NSAID's as many authors have cautioned against their use in this setting. Concerns about their impact on coagulation and renal function as well as a risk for gastrointestinal bleeding have been raised. However, many of the adverse effects reported have occurred during long term treatment and might not be directly applicable to the perioperative period. Still the clinician must be aware of the potential risks and benefits of these drugs. This review focuses on the pro's and con's of perioperative NSAID usage. We address the background for a multimodal approach to postoperative pain relief as well as potential alternatives to NSAID's and the recently introduced COX2-selective inhibitors.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)

Keyword

Kidney Failure

Human

Non-Steroidal : adverse effects

Anti-Inflammatory Agents

Non-Steroidal : contraindications

Cyclooxygenase Inhibitors : administration & dosage

Cyclooxygenase Inhibitors : adverse effects

Drug Hypersensitivity : etiology

English Abstract

Gastrointestinal Hemorrhage : chemically induced

Non-Steroidal : administration & dosage

Cyclooxygenase Inhibitors : contraindications

Acute : chemically induced

Pain

Postoperative : drug therapy

Postoperative : prevention & control

Platelet Aggregation : drug effects

Publication and Content Type

art (subject category)

ref (subject category)