Search: onr:"swepub:oai:lup.lub.lu.se:f2c503df-d354-4dd1-b974-be514b1a9977" >
Dynamic 2D and 3D m...
-
Müller, Christoph A.Albert-Ludwigs University Freiburg,German Cancer Research Centre
(author)
Dynamic 2D and 3D mapping of hyperpolarized pyruvate to lactate conversion in vivo with efficient multi-echo balanced steady-state free precession at 3 T
- Article/chapterEnglish2020
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:f2c503df-d354-4dd1-b974-be514b1a9977
-
https://lup.lub.lu.se/record/f2c503df-d354-4dd1-b974-be514b1a9977URI
-
https://doi.org/10.1002/nbm.4291DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
The aim of this study was to acquire the transient MRI signal of hyperpolarized tracers and their metabolites efficiently, for which specialized imaging sequences are required. In this work, a multi-echo balanced steady-state free precession (me-bSSFP) sequence with Iterative Decomposition with Echo Asymmetry and Least squares estimation (IDEAL) reconstruction was implemented on a clinical 3 T positron-emission tomography/MRI system for fast 2D and 3D metabolic imaging. Simulations were conducted to obtain signal-efficient sequence protocols for the metabolic imaging of hyperpolarized biomolecules. The sequence was applied in vitro and in vivo for probing the enzymatic exchange of hyperpolarized [1–13C]pyruvate and [1–13C]lactate. Chemical shift resolution was achieved using a least-square, iterative chemical species separation algorithm in the reconstruction. In vitro, metabolic conversion rate measurements from me-bSSFP were compared with NMR spectroscopy and free induction decay-chemical shift imaging (FID-CSI). In vivo, a rat MAT-B-III tumor model was imaged with me-bSSFP and FID-CSI. 2D metabolite maps of [1–13C]pyruvate and [1–13C]lactate acquired with me-bSSFP showed the same spatial distributions as FID-CSI. The pyruvate-lactate conversion kinetics measured with me-bSSFP and NMR corresponded well. Dynamic 2D metabolite mapping with me-bSSFP enabled the acquisition of up to 420 time frames (scan time: 180-350 ms/frame) before the hyperpolarized [1–13C]pyruvate was relaxed below noise level. 3D metabolite mapping with a large field of view (180 × 180 × 48 mm3) and high spatial resolution (5.6 × 5.6 × 2 mm3) was conducted with me-bSSFP in a scan time of 8.2 seconds. It was concluded that Me-bSSFP improves the spatial and temporal resolution for metabolic imaging of hyperpolarized [1–13C]pyruvate and [1–13C]lactate compared with either of the FID-CSI or EPSI methods reported at 3 T, providing new possibilities for clinical and preclinical applications.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Hundshammer, ChristianKlinikum rechts der Isar
(author)
-
Braeuer, MiriamKlinikum rechts der Isar
(author)
-
Skinner, Jason G.Klinikum rechts der Isar,Albert-Ludwigs University Freiburg
(author)
-
Berner, StephanGerman Cancer Research Centre,Albert-Ludwigs University Freiburg
(author)
-
Leupold, JochenAlbert-Ludwigs University Freiburg
(author)
-
Düwel, StephanKlinikum rechts der Isar
(author)
-
Nekolla, Stephan G.Klinikum rechts der Isar
(author)
-
Månsson, SvenLund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)ront-sma
(author)
-
Hansen, Adam E.University of Copenhagen
(author)
-
von Elverfeldt, DominikAlbert-Ludwigs University Freiburg
(author)
-
Ardenkjaer-Larsen, Jan H.Technical University of Denmark
(author)
-
Schilling, FranzKlinikum rechts der Isar
(author)
-
Schwaiger, MarkusKlinikum rechts der Isar
(author)
-
Hennig, JürgenAlbert-Ludwigs University Freiburg
(author)
-
Hövener, Jan BerndAlbert-Ludwigs University Freiburg,University Medical Center Schleswig-Holstein
(author)
-
Albert-Ludwigs University FreiburgGerman Cancer Research Centre
(creator_code:org_t)
Related titles
-
In:NMR in Biomedicine: Wiley33:60952-34801099-1492
Internet link
Find in a library
To the university's database
- By the author/editor
-
Müller, Christop ...
-
Hundshammer, Chr ...
-
Braeuer, Miriam
-
Skinner, Jason G ...
-
Berner, Stephan
-
Leupold, Jochen
-
show more...
-
Düwel, Stephan
-
Nekolla, Stephan ...
-
Månsson, Sven
-
Hansen, Adam E.
-
von Elverfeldt, ...
-
Ardenkjaer-Larse ...
-
Schilling, Franz
-
Schwaiger, Marku ...
-
Hennig, Jürgen
-
Hövener, Jan Ber ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Radiology Nuclea ...
-
- ENGINEERING AND TECHNOLOGY
-
ENGINEERING AND ...
-
and Electrical Engin ...
-
and Signal Processin ...
- Articles in the publication
-
NMR in Biomedici ...
- By the university
-
Lund University