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A Consensus Molecul...
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Kamoun, AurélieLigue Nationale Contre le Cancer
(author)
A Consensus Molecular Classification of Muscle-invasive Bladder Cancer
- Article/chapterEnglish2020
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LIBRIS-ID:oai:lup.lub.lu.se:f2d670e5-790e-4022-a244-df6fe5a6361a
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https://lup.lub.lu.se/record/f2d670e5-790e-4022-a244-df6fe5a6361aURI
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https://doi.org/10.1016/j.eururo.2019.09.006DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Background: Muscle-invasive bladder cancer (MIBC) is a molecularly diverse disease with heterogeneous clinical outcomes. Several molecular classifications have been proposed, but the diversity of their subtype sets impedes their clinical application. Objective: To achieve an international consensus on MIBC molecular subtypes that reconciles the published classification schemes. Design, setting, and participants: We used 1750 MIBC transcriptomic profiles from 16 published datasets and two additional cohorts. Outcome measurements and statistical analysis: We performed a network-based analysis of six independent MIBC classification systems to identify a consensus set of molecular classes. Association with survival was assessed using multivariable Cox models. Results and limitations: We report the results of an international effort to reach a consensus on MIBC molecular subtypes. We identified a consensus set of six molecular classes: luminal papillary (24%), luminal nonspecified (8%), luminal unstable (15%), stroma-rich (15%), basal/squamous (35%), and neuroendocrine-like (3%). These consensus classes differ regarding underlying oncogenic mechanisms, infiltration by immune and stromal cells, and histological and clinical characteristics, including outcomes. We provide a single-sample classifier that assigns a consensus class label to a tumor sample's transcriptome. Limitations of the work are retrospective clinical data collection and a lack of complete information regarding patient treatment. Conclusions: This consensus system offers a robust framework that will enable testing and validation of predictive biomarkers in future prospective clinical trials. Patient summary: Bladder cancers are heterogeneous at the molecular level, and scientists have proposed several classifications into sets of molecular classes. While these classifications may be useful to stratify patients for prognosis or response to treatment, a consensus classification would facilitate the clinical use of molecular classes. Conducted by multidisciplinary expert teams in the field, this study proposes such a consensus and provides a tool for applying the consensus classification in the clinical setting.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Reyniès, Aurélien deLigue Nationale Contre le Cancer
(author)
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Allory, YvesCurie Institute, Paris
(author)
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Sjödahl, GottfridLund University,Lunds universitet,Genomiska analyser av urinblåscancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urothelial Cancer Genomics,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)med-gsj
(author)
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Gordon Robertson, A.British Columbia Cancer Agency
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Seiler, RolandBern University Hospital
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Hoadley, Katherine A.University of North Carolina
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Groeneveld, Clarice S.Curie Institute, Paris,Ligue Nationale Contre le Cancer,Federal University of Paraná
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Al-Ahmadie, HikmatMemorial Sloan-Kettering Cancer Center
(author)
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Choi, WoonyoungJohns Hopkins University
(author)
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Castro, Mauro A.A.Federal University of Paraná
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Fontugne, JacquelineCurie Institute, Paris
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Eriksson, PontusLund University,Lunds universitet,Genomiska analyser av urinblåscancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urothelial Cancer Genomics,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)med-pte
(author)
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Mo, QianxingH. Lee Moffitt Cancer Center & Research Institute
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Kardos, JordanUniversity of North Carolina
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Zlotta, AlexandreUniversity of Toronto,Mount Sinai Hospital of University of Toronto
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Hartmann, ArndtFriedrich-Alexander University Erlangen-Nürnberg
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Dinney, Colin P.University of Texas
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Bellmunt, JoaquimHarvard University
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Powles, ThomasQueen Mary University,National Health Service Trust, NHS England
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Malats, NúriaSpanish National Cancer Research Center (CNIO)
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Chan, Keith S.Cedars-Sinai Medical Center
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Kim, William Y.University of North Carolina
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McConkey, David J.Johns Hopkins University
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Black, Peter C.University of British Columbia
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Dyrskjøt, LarsAarhus University Hospital
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Höglund, MattiasLund University,Lunds universitet,Genomiska analyser av urinblåscancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urothelial Cancer Genomics,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)kgen-mho
(author)
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Lerner, Seth P.Baylor College of Medicine
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Real, Francisco X.Spanish National Cancer Research Center (CNIO)
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Radvanyi, FrançoisCurie Institute, Paris
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Liedberg, FredrikLund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urinblåsecancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Urology - urothelial cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Urothelial cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)urok-fli
(creator_code:cre_t)
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Ligue Nationale Contre le CancerCurie Institute, Paris
(creator_code:org_t)
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Bladder Cancer Molecular Taxonomy Group
Related titles
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In:European Urology: Elsevier BV77:4, s. 420-4330302-2838
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Kamoun, Aurélie
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Reyniès, Aurélie ...
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Allory, Yves
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Sjödahl, Gottfri ...
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Gordon Robertson ...
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Seiler, Roland
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Hoadley, Katheri ...
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Groeneveld, Clar ...
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Al-Ahmadie, Hikm ...
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Castro, Mauro A. ...
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Fontugne, Jacque ...
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Eriksson, Pontus
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Mo, Qianxing
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Kardos, Jordan
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Zlotta, Alexandr ...
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Hartmann, Arndt
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Dinney, Colin P.
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Bellmunt, Joaqui ...
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Powles, Thomas
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Malats, Núria
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Chan, Keith S.
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Kim, William Y.
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McConkey, David ...
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Black, Peter C.
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Dyrskjøt, Lars
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Höglund, Mattias
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Lerner, Seth P.
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Real, Francisco ...
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European Urology
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Lund University