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Ventilation-Perfusi...
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Jögi, JonasLund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
(author)
Ventilation-Perfusion SPECT with Tc-99m-DTPA Versus Technegas: A Head-to-Head Study in Obstructive and Nonobstructive Disease
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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2010-04-15
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Society of Nuclear Medicine,2010
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LIBRIS-ID:oai:lup.lub.lu.se:f2dc6116-e4a4-4a06-bc7d-f09cd98244bf
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https://lup.lub.lu.se/record/1619384URI
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https://doi.org/10.2967/jnumed.109.073957DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Lung scintigraphy is primarily used to diagnose pulmonary embolism. Ventilation imaging is often performed using Tc-99m-DTPA or Technegas, an ultrafine dispersion of Tc-99m-labeled carbon. Despite the common use of these radioaerosols, they have not been compared in an intraindividual study, and not with ventilation-perfusion (V/P) SPECT. The aim of the present head-to-head study was to systematically investigate differences in ventilation studies performed with Tc-99m-diethylenetriaminepentaacetate (DTPA) and Technegas. Methods: Sixty-three patients, 28 without and 35 with obstructive lung disease, were examined with V/P SPECT using both Tc-99m-DTPA and Technegas. V/P SPECT images were randomized and assessed independently by 2 masked physicians according to a predefined scoring system. A paired comparison was performed using the Wilcoxon signed-rank test. Results: In both obstructive and nonobstructive disease, the overall unevenness of radiotracer deposition and the degree of central deposition were more pronounced in Tc-99m-DTPA than Technegas studies. Because of better peripheral penetration, the extent of reverse mismatch was less when Technegas was used. Additionally, in obstructive disease, the degree of focal deposition in distal airways was more pronounced with Tc-99m-DTPA. Mismatched perfusion defects were more frequently found with Technegas in obstructive disease. Conclusion: This intraindividual comparative study shows that Technegas is the preferred radioaerosol, particularly in obstructive disease.
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Jonson, BjörnLund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)klfy-bjo
(author)
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Ekberg, MarieLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)lung-mek
(author)
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Bajc, MarikaLund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)klfy-mba
(author)
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Klinisk fysiologi, LundSektion V
(creator_code:org_t)
Related titles
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In:Journal of Nuclear Medicine: Society of Nuclear Medicine51:5, s. 735-7410161-55052159-662X
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