A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population

Brorsson, Caroline (author)

Bergholdt, Regine (author)

Sjögren, Marketa (author): Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups

Eising, Stefanie (author)

Sorensen, Karina Meden (author)

Hougaard, David M. (author)

Orho-Melander, Marju (author): Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups

Groop, Leif (author): Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups

Pociot, Flemming (author)

(creator_code:org_t)

Elsevier BV, 2008
2008
English.
In: Molecular Genetics and Metabolism. - : Elsevier BV. - 1096-7192. ; 94:3, s. 386-388

Related links:: http://dx.doi.org/10...; show more...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Abstract Subject headings

Genome-wide association scans in type 2 diabetes (T2D) have identified a risk variant, rs13266634 (Arg325Trp), in SLC30A8 on chromosome 8. SLC30A8 encodes a beta-cell specific zinc-ion transporter and rs13266634 has been shown to affect insulin secretion. Recently, autoantibodies for Slc30A8 with high predictive value were demonstrated in individuals with type 1 diabetes (T1 D), making this gene an interesting T1 D candidate gene. We genotyped rs13266634 in 3008 cases and controls and 246 families from Denmark. Association to T1 D could not be demonstrated.

By the author/editor: Brorsson, Caroli ...; Bergholdt, Regin ...; Sjögren, Marketa; Eising, Stefanie; Sorensen, Karina ...; Hougaard, David ...; show more...; Orho-Melander, M ...; Groop, Leif; Pociot, Flemming; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

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