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The dentate gyrus in hypoglycemia : Pathology implicating excititoxin-mediated neuronal necrosis
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- Auer, R. (author)
- Lund University,University of Turku
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- Kalimo, H. (author)
- University of Gothenburg
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- Olsson, Y. (author)
- Uppsala University
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- (creator_code:org_t)
- 1985
- 1985
- English 10 s.
- In: Acta Neuropathologica. - 0001-6322. ; 67:3-4, s. 279-288
- Journal article (peer-reviewed)
Abstract
Subject headings
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- A detailed light- and electron-microscopic study of the damage to the rat dentate gyrus in hypoglycemia was undertaken, in view of the previously advanced hypothesis that hypoglycemic nerve cell injury is mediated by a released neurotoxin. The distribution of neuronal necrosis showed a relationship to the subarachnoid cisterns. Electron microscopy of the dentate granule cells and their apical dendrites revealed dendrosomal, axon-sparing neuronal pathology. Dentate granule cells were affected first in the dendrites in the outer layer of the stratum moleculare, sparing axons of passage and terminal boutons. Subsequently, the neuronal perikarya were affected, and Wallerian degeneration of axons followed. Cell membrane abnormalities preceded the appearance of mitochondrial flocculent densities and degradation of the cytoskeleton, and are suggested to be early lethal changes. The observed early dendrotoxic changes, and the dendrosomal, axon-sparing nature of the lesion implicate an excitotoxin-mediated neuronal necrosis in hypoglycemia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Cerebrospinal fluid (CSF)
- Dendrites
- Dentate
- Excitotoxin
- Hypoglycemia
- Membrane breaks
- Neuronal necrosis
Publication and Content Type
- art (subject category)
- ref (subject category)
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- Kalimo, H.
- Olsson, Y.
- Wieloch, T.
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
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- Lund University
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