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Causes and risk fac...
Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database
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Tyndall, Anthony J. (author)
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Bannert, Bettina (author)
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Vonk, Madelon (author)
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Airo, Paolo (author)
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Cozzi, Franco (author)
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Carreira, Patricia E. (author)
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Bancel, Dominique Farge (author)
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Allanore, Yannick (author)
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Mueller-Ladner, Ulf (author)
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Distler, Oliver (author)
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Iannone, Florenzo (author)
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Pellerito, Raffaele (author)
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Pileckyte, Margarita (author)
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Miniati, Irene (author)
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Ananieva, Lidia (author)
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Gurman, Alexandra Balbir (author)
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Damjanov, Nemanja (author)
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Mueller, Adelheid (author)
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Valentini, Gabriele (author)
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Riemekasten, Gabriela (author)
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Tikly, Mohammed (author)
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Hummers, Laura (author)
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Henriques, Maria J. S. (author)
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Caramaschi, Paola (author)
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- Scheja, Agneta (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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Rozman, Blaz (author)
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Ton, Evelien (author)
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Kumanovics, Gabor (author)
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Coleiro, Bernard (author)
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Feierl, Eva (author)
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Szucs, Gabriella (author)
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Von Muehlen, Carlos Alberto (author)
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Riccieri, Valeria (author)
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Novak, Srdan (author)
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Chizzolini, Carlo (author)
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Kotulska, Anna (author)
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Denton, Christopher (author)
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Coelho, Paulo C. (author)
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Koetter, Ina (author)
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Simsek, Ismail (author)
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de la Pena Lefebvre, Paloma Garcia (author)
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Hachulla, Eric (author)
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Seibold, James R. (author)
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Rednic, Simona (author)
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Stork, Jiri (author)
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Morovic-Vergles, Jadranka (author)
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Walker, Ulrich A. (author)
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(creator_code:org_t)
- 2010-06-15
- 2010
- English.
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In: Annals of the Rheumatic Diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 69:10, s. 1809-1815
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Objectives To determine the causes and predictors of mortality in systemic sclerosis (SSc). Methods Patients with SSc (n=5860) fulfilling the American College of Rheumatology criteria and prospectively followed in the EULAR Scleroderma Trials and Research (EUSTAR) cohort were analysed. EUSTAR centres completed a structured questionnaire on cause of death and comorbidities. Kaplan-Meier and Cox proportional hazards models were used to analyse survival in SSc subgroups and to identify predictors of mortality. Results Questionnaires were obtained on 234 of 284 fatalities. 55% of deaths were attributed directly to SSc and 41% to non-SSc causes; in 4% the cause of death was not assigned. Of the SSc-related deaths, 35% were attributed to pulmonary fibrosis, 26% to pulmonary arterial hypertension (PAH) and 26% to cardiac causes (mainly heart failure and arrhythmias). Among the non-SSc-related causes, infections (33%) and malignancies (31%) were followed by cardiovascular causes (29%). Of the non-SSc-related fatalities, 25% died of causes in which SSc-related complications may have participated (pneumonia, sepsis and gastrointestinal haemorrhage). Independent risk factors for mortality and their HR were: proteinuria (HR 3.34), the presence of PAH based on echocardiography (HR 2.02), pulmonary restriction (forced vital capacity below 80% of normal, HR 1.64), dyspnoea above New York Heart Association class II (HR 1.61), diffusing capacity of the lung (HR 1.20 per 10% decrease), patient age at onset of Raynaud's phenomenon (HR 1.30 per 10 years) and the modified Rodnan skin score (HR 1.20 per 10 score points). Conclusion Disease-related causes, in particular pulmonary fibrosis, PAH and cardiac causes, accounted for the majority of deaths in SSc.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Tyndall, Anthony ...
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Bannert, Bettina
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Vonk, Madelon
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Airo, Paolo
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Cozzi, Franco
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Carreira, Patric ...
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show more...
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Bancel, Dominiqu ...
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Allanore, Yannic ...
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Mueller-Ladner, ...
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Distler, Oliver
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Iannone, Florenz ...
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Pellerito, Raffa ...
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Pileckyte, Marga ...
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Miniati, Irene
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Ananieva, Lidia
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Gurman, Alexandr ...
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Damjanov, Nemanj ...
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Mueller, Adelhei ...
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Valentini, Gabri ...
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Riemekasten, Gab ...
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Tikly, Mohammed
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Hummers, Laura
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Henriques, Maria ...
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Caramaschi, Paol ...
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Scheja, Agneta
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Rozman, Blaz
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Ton, Evelien
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Kumanovics, Gabo ...
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Coleiro, Bernard
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Feierl, Eva
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Szucs, Gabriella
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Von Muehlen, Car ...
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Riccieri, Valeri ...
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Novak, Srdan
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Chizzolini, Carl ...
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Kotulska, Anna
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Denton, Christop ...
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Coelho, Paulo C.
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Koetter, Ina
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Simsek, Ismail
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de la Pena Lefeb ...
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Hachulla, Eric
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Seibold, James R ...
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Rednic, Simona
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Stork, Jiri
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Morovic-Vergles, ...
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Walker, Ulrich A ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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Annals of the Rh ...
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Lund University