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Causes and risk fac...
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Tyndall, Anthony J.
(author)
Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database
- Article/chapterEnglish2010
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LIBRIS-ID:oai:lup.lub.lu.se:f4a25a54-4299-4d39-bbc2-2a566834ad48
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https://lup.lub.lu.se/record/1696109URI
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https://doi.org/10.1136/ard.2009.114264DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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Objectives To determine the causes and predictors of mortality in systemic sclerosis (SSc). Methods Patients with SSc (n=5860) fulfilling the American College of Rheumatology criteria and prospectively followed in the EULAR Scleroderma Trials and Research (EUSTAR) cohort were analysed. EUSTAR centres completed a structured questionnaire on cause of death and comorbidities. Kaplan-Meier and Cox proportional hazards models were used to analyse survival in SSc subgroups and to identify predictors of mortality. Results Questionnaires were obtained on 234 of 284 fatalities. 55% of deaths were attributed directly to SSc and 41% to non-SSc causes; in 4% the cause of death was not assigned. Of the SSc-related deaths, 35% were attributed to pulmonary fibrosis, 26% to pulmonary arterial hypertension (PAH) and 26% to cardiac causes (mainly heart failure and arrhythmias). Among the non-SSc-related causes, infections (33%) and malignancies (31%) were followed by cardiovascular causes (29%). Of the non-SSc-related fatalities, 25% died of causes in which SSc-related complications may have participated (pneumonia, sepsis and gastrointestinal haemorrhage). Independent risk factors for mortality and their HR were: proteinuria (HR 3.34), the presence of PAH based on echocardiography (HR 2.02), pulmonary restriction (forced vital capacity below 80% of normal, HR 1.64), dyspnoea above New York Heart Association class II (HR 1.61), diffusing capacity of the lung (HR 1.20 per 10% decrease), patient age at onset of Raynaud's phenomenon (HR 1.30 per 10 years) and the modified Rodnan skin score (HR 1.20 per 10 score points). Conclusion Disease-related causes, in particular pulmonary fibrosis, PAH and cardiac causes, accounted for the majority of deaths in SSc.
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Bannert, Bettina
(author)
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Vonk, Madelon
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Airo, Paolo
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Cozzi, Franco
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Carreira, Patricia E.
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Bancel, Dominique Farge
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Allanore, Yannick
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Mueller-Ladner, Ulf
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Distler, Oliver
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Iannone, Florenzo
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Pellerito, Raffaele
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Pileckyte, Margarita
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Miniati, Irene
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Ananieva, Lidia
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Gurman, Alexandra Balbir
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Damjanov, Nemanja
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Mueller, Adelheid
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Valentini, Gabriele
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Riemekasten, Gabriela
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Tikly, Mohammed
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Hummers, Laura
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Henriques, Maria J. S.
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Caramaschi, Paola
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Scheja, AgnetaLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-asc
(author)
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Rozman, Blaz
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Ton, Evelien
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Kumanovics, Gabor
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Coleiro, Bernard
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Feierl, Eva
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Szucs, Gabriella
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Von Muehlen, Carlos Alberto
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Riccieri, Valeria
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Novak, Srdan
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Chizzolini, Carlo
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Kotulska, Anna
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Denton, Christopher
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Coelho, Paulo C.
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Koetter, Ina
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Simsek, Ismail
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de la Pena Lefebvre, Paloma Garcia
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Hachulla, Eric
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Seibold, James R.
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Rednic, Simona
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Stork, Jiri
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Morovic-Vergles, Jadranka
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Walker, Ulrich A.
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Reumatologi och molekylär skelettbiologiSektion III
(creator_code:org_t)
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In:Annals of the Rheumatic Diseases: BMJ69:10, s. 1809-18151468-20600003-4967
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Tyndall, Anthony ...
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Bannert, Bettina
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Vonk, Madelon
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Airo, Paolo
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Cozzi, Franco
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Carreira, Patric ...
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Bancel, Dominiqu ...
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Allanore, Yannic ...
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Mueller-Ladner, ...
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Distler, Oliver
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Iannone, Florenz ...
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Pellerito, Raffa ...
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Pileckyte, Marga ...
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Miniati, Irene
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Ananieva, Lidia
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Gurman, Alexandr ...
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Damjanov, Nemanj ...
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Mueller, Adelhei ...
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Valentini, Gabri ...
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Riemekasten, Gab ...
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Tikly, Mohammed
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Hummers, Laura
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Henriques, Maria ...
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Caramaschi, Paol ...
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Scheja, Agneta
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Rozman, Blaz
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Ton, Evelien
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Kumanovics, Gabo ...
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Coleiro, Bernard
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Feierl, Eva
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Szucs, Gabriella
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Von Muehlen, Car ...
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Riccieri, Valeri ...
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Novak, Srdan
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Chizzolini, Carl ...
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Kotulska, Anna
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Denton, Christop ...
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Coelho, Paulo C.
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Koetter, Ina
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Simsek, Ismail
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de la Pena Lefeb ...
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Hachulla, Eric
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Seibold, James R ...
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Rednic, Simona
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Stork, Jiri
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Morovic-Vergles, ...
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Walker, Ulrich A ...
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