onr:"swepub:oai:lup.lub.lu.se:f4f404ff-4c1a-41d8-a794-b5c5d4fc4ff2"
Search: onr:"swepub:oai:lup.lub.lu.se:f4f404ff-4c1a-41d8-a794-b5c5d4fc4ff2" > Human achaete-scute...
- 1 of 1
- Previous record
- Next record
- To hitlist
Human achaete-scute homologue 1 (HASH-1) is downregulated in differentiating neuroblastoma cells
-
- Söderholm, Helena, 1969- (author)
- Uppsala universitet,Institutionen för patologi,Sven Påhlman
-
- Örtoft, Eva (author)
- Department of Laboratory Medicine, Division of Molecular Medicine, Lund University, Malmö, Sweden
-
- Johansson, Irja (author)
- Department of Laboratory Medicine, Division of Molecular Medicine, Lund University, Malmö, Sweden
- show more...
- show less...
- (creator_code:org_t)
- Elsevier BV, 1999
- 1999
- English.
- In: Biochemical and Biophysical Research Communications. - : Elsevier BV. - 1090-2104 .- 0006-291X. ; 256:3, s. 557-563
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The mammalian achaete-scute homologue, MASH-1, is crucial for early development of the sympathetic nervous system and is transiently expressed in sympathetic neuroblasts during embryogenesis. Here we report that the human homologue (HASH-1) was expressed in all analyzed cell lines (6/6) derived from the sympathetic nervous system tumor neuroblastoma. The majority of small-cell lung carcinoma (4/5) cell lines tested expressed HASH-1, while other nonneuronal/non-neuroendocrine cell lines were negative. Induced differentiation of neuroblastoma cells resulted in HASH-1 downregulation. This occurred concomitant with induction of neurite outgrowth and expression of the neuronal marker genes GAP-43 and neuropeptide Y. Constitutive expression of exogenous HASH-1 did not alter the capacity of the neuroblastoma cells to differentiate in response to differentiation-inducing agents. It is concluded that moderate HASH-1 expression does not compromise the capacity of these cells to differentiate.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
- Biochemical and Biophysical Research Communications (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Söderholm, Helen ...
- Örtoft, Eva
- Johansson, Irja
- Ljungberg, June
- Larsson, Christe ...
- Axelson, Håkan
- show more...
- Påhlman, Sven
- show less...
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- Articles in the publication
- Biochemical and ...
- By the university
- Lund University
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
