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Oxidative stress, i...
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Lindqvist, DanielLund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,University of California, San Francisco
(author)
Oxidative stress, inflammation and treatment response in major depression
- Article/chapterEnglish2016
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LIBRIS-ID:oai:lup.lub.lu.se:f596990f-a052-40c3-ae08-851a35e95d39
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https://lup.lub.lu.se/record/f596990f-a052-40c3-ae08-851a35e95d39URI
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https://doi.org/10.1016/j.psyneuen.2016.11.031DOI
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Language:English
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Summary in:English
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OBJECTIVE: Increased inflammation and oxidative stress have been shown in Major Depressive Disorder (MDD), although there is significant heterogeneity across studies. Whether markers of inflammation and oxidative stress are associated with antidepressant treatment response in MDD is currently unclear. The goals of the present study are to investigate markers of inflammation and oxidative stress in unmedicated MDD subjects and controls and test the relationship between these markers and antidepressant response in MDD subjects.METHODS: Interleukin (IL)-6, tumor necrosis factor (TNF)-α, C-reactive protein, F2-isoprostanes, 8-OH 2-deoxyguanosine (8-OHdG), glutathione peroxidase, glutathione, and vitamin C were quantified in blood samples from 50 unmedicated MDD subjects and 55 healthy controls. Depression symptom severity was rated with the 17-item Hamilton Depression Rating Scale (HDRS). All subjects were somatically healthy and free from medications that could interfere with inflammation and oxidative stress markers. A subgroup of 22 MDD subjects underwent open-label selective serotonin reuptake inhibitor (SSRI) antidepressant treatment for eight weeks, after which blood sampling and the HDRS were repeated. Antidepressant treatment "response" was defined as ≥50% decrease in HDRS ratings over 8 weeks of treatment.RESULTS: After controlling for the effects of age, sex, body mass index and smoking, MDD subjects had significantly higher levels of IL-6 (p<0.001), TNF-α (p<0.001), 8-OHdG (p=0.018), and F2-isoprostanes (p=0.012). Compared to Responders, Non-responders to SSRI antidepressant treatment had higher levels of F2-isoprostanes at baseline (p=0.006), and after eight weeks of treatment (p=0.031). Non-responders showed a significant increase in 8-OHdG over the course of treatment (p=0.021), whereas Responders showed a significant decrease in IL-6 over the course of treatment (p=0.019).CONCLUSION: Our results are in line with previous reports of increased levels of markers of inflammation and oxidative stress in MDD. Moreover, poorer antidepressant treatment response was related to higher baseline levels of the major oxidative stress marker, F2-isoprostanes, in vivo. Further, antidepressant response was associated with changes in oxidative (8-OHdG) and inflammatory (IL-6) markers.
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Dhabhar, Firdaus SUniversity of Miami
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James, S JillUniversity of Arkansas for Medical Sciences
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Hough, Christina MUniversity of California, San Francisco
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Jain, Felipe AUniversity of California, San Francisco
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Bersani, F SaverioUniversity of California, San Francisco,Sapienza University of Rome
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Reus, Victor IUniversity of California, San Francisco
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Verhoeven, Josine EAmsterdam UMC - Vrije Universiteit Amsterdam,University of California, San Francisco
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Epel, Elissa SUniversity of California, San Francisco
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Mahan, LauraUniversity of California, San Francisco
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Rosser, RebeccaUniversity of California, San Francisco
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Wolkowitz, Owen MUniversity of California, San Francisco
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Mellon, Synthia HUniversity of California, San Francisco
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Psykiatri, LundSektion IV
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In:Psychoneuroendocrinology: Elsevier BV76, s. 197-2051873-33600306-4530
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