Search: onr:"swepub:oai:lup.lub.lu.se:f6a06aaa-47ba-4e9e-8ef1-5b77345fd6a4" >
Inflammation-induce...
-
Vuttaradhi, Veena KumariIndian Institute of Technology Madras
(author)
Inflammation-induced PELP1 expression promotes tumorigenesis by activating GM-CSF paracrine secretion in the tumor microenvironment
- Article/chapterEnglish2022
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:f6a06aaa-47ba-4e9e-8ef1-5b77345fd6a4
-
https://lup.lub.lu.se/record/f6a06aaa-47ba-4e9e-8ef1-5b77345fd6a4URI
-
https://doi.org/10.1016/j.jbc.2021.101406DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
The inflammatory tumor microenvironment has been implicated as a major player fueling tumor progression and an enabling characteristic of cancer, proline, glutamic acid, and leucine-rich protein 1 (PELP1) is a novel nuclear receptor coregulator that signals across diverse signaling networks, and its expression is altered in several cancers. However, investigations to find the role of PELP1 in inflammation-driven oncogenesis are limited. Molecular studies here, utilizing macrophage cell lines and animal models upon stimulation with lipopolysaccharide (LPS) or necrotic cells, showed that PELP1 is an inflammation-inducible gene. Studies on the PELP1 promoter and its mutant identified potential binding of c-Rel, an NF-κB transcription factor subunit, to PELP1 promoter upon LPS stimulation in macrophages. Recruitment of c-Rel onto the PELP1 promoter was validated by chromatin immunoprecipitation, further confirming LPS mediated PELP1 expression through c-Rel–specific transcriptional regulation. Macrophages that overexpress PELP1 induces granulocyte–macrophage colony-stimulating factor secretion, which mediates cancer progression in a paracrine manner. Results from preclinical studies with normal–inflammatory–tumor progression models demonstrated a progressive increase in the PELP1 expression, supporting this link between inflammation and cancer. In addition, animal studies demonstrated the connection of PELP1 in inflammation-directed cancer progression. Taken together, our findings provide the first report on c-Rel–specific transcriptional regulation of PELP1 in inflammation and possible granulocyte–macrophage colony-stimulating factor–mediated transformation potential of activated macrophages on epithelial cells in the inflammatory tumor microenvironment, reiterating the link between PELP1 and inflammation-induced oncogenesis. Understanding the regulatory mechanisms of PELP1 may help in designing better therapeutics to cure various inflammation-associated malignancies.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Ezhil, InemaiIndian Institute of Technology Madras
(author)
-
Ramani, DivyaIndian Institute of Technology Madras,Sri Ramachandra University
(author)
-
Kanumuri, RahulSri Ramachandra University,Indian Institute of Technology Madras
(author)
-
Raghavan, SwethaIndian Institute of Technology Madras
(author)
-
Balasubramanian, VaishnaviSri Ramachandra University
(author)
-
Saravanan, RoshniSri Ramachandra University
(author)
-
Kanakarajan, ArchanaSri Ramachandra University
(author)
-
Joseph, Leena DennisSri Ramachandra University
(author)
-
Pitani, Ravi ShankarSri Ramachandra University
(author)
-
Sundaram, SandhyaSri Ramachandra University
(author)
-
Sjölander, AnitaLund University,Lunds universitet,Cellpatologi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Cell Pathology, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)expp-asj
(author)
-
Venkatraman, GaneshSri Ramachandra University
(author)
-
Rayala, Suresh KumarIndian Institute of Technology Madras
(author)
-
Indian Institute of Technology MadrasSri Ramachandra University
(creator_code:org_t)
Related titles
-
In:Journal of Biological Chemistry: Elsevier BV298:10021-9258
Internet link
Find in a library
To the university's database
- By the author/editor
-
Vuttaradhi, Veen ...
-
Ezhil, Inemai
-
Ramani, Divya
-
Kanumuri, Rahul
-
Raghavan, Swetha
-
Balasubramanian, ...
-
show more...
-
Saravanan, Roshn ...
-
Kanakarajan, Arc ...
-
Joseph, Leena De ...
-
Pitani, Ravi Sha ...
-
Sundaram, Sandhy ...
-
Sjölander, Anita
-
Venkatraman, Gan ...
-
Rayala, Suresh K ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Journal of Biolo ...
- By the university
-
Lund University