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Effects of Whole Br...
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Liu, JiyunLinnéuniversitetet,Linnaeus University,Institutionen för kemi och biomedicin (KOB),Hållbar hälsa
(author)
Effects of Whole Brown Bean and Its Isolated Fiber Fraction on Plasma Lipid Profile, Atherosclerosis, Gut Microbiota, and Microbiota-Dependent Metabolites in Apoe-/- Mice
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-02-22
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MDPI AG,2022
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17 s.
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:f70e7594-9ff0-4225-9109-2f4aa57105f2
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https://lup.lub.lu.se/record/f70e7594-9ff0-4225-9109-2f4aa57105f2URI
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https://doi.org/10.3390/nu14050937DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-111013URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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The health benefits of bean consumption are widely recognized and are largely attributed to the dietary fiber content. This study investigated and compared the effects of whole brown beans and an isolated bean dietary fiber fraction on the plasma lipid profile, atherosclerotic plaque amount, gut microbiota, and microbiota-dependent metabolites (cecal short-chain fatty acids (SCFAs) and plasma methylamines) in Apoe−/− mice fed high fat diets for 10.5 weeks. The results showed that both whole bean and the isolated fiber fraction had a tendency to lower atherosclerotic plaque amount, but not plasma lipid concentration. The whole bean diet led to a significantly higher diversity of gut microbiota compared with the high fat diet. Both bean diets resulted in a lower Firmicutes/Bacteroidetes ratio, higher relative abundance of unclassified S24-7, Prevotella, Bifidobacterium, and unclassified Clostridiales, and lower abundance of Lactobacillus. Both bean diets resulted in higher formation of all cecal SCFAs (higher proportion of propionic acid and lower proportion of acetic acid) and higher plasma trimethylamine N-oxide concentrations compared with the high fat diet. Whole beans and the isolated fiber fraction exerted similar positive effects on atherosclerotic plaque amount, gut microbiota, and cecal SCFAs in Apoe−/− mice compared with the control diets.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Hefni, Mohammed E.Linnéuniversitetet,Linnaeus University,Mansoura University, Egypt,Institutionen för kemi och biomedicin (KOB),Hållbar hälsa(Swepub:lnu)moheaa
(author)
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Witthöft, Cornelia M.Linnéuniversitetet,Linnaeus University,Institutionen för kemi och biomedicin (KOB),Hållbar hälsa(Swepub:lnu)cowiab
(author)
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Bergström, MariaLinnéuniversitetet,Linnaeus University,Institutionen för kemi och biomedicin (KOB),Hållbar hälsa(Swepub:lnu)nbema
(author)
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Burleigh, StephenLund University,Lunds universitet,Avdelningen för livsmedel och läkemedel,Institutionen för processteknik och tillämpad biovetenskap,Institutioner vid LTH,Lunds Tekniska Högskola,Division of Food and Pharma,Department of Process and Life Science Engineering,Departments at LTH,Faculty of Engineering, LTH,Lund University, Sweden(Swepub:lu)mbio-sbu
(author)
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Nyman, MargaretaLund University,Lunds universitet,Avdelningen för livsmedel och läkemedel,Institutionen för processteknik och tillämpad biovetenskap,Institutioner vid LTH,Lunds Tekniska Högskola,Division of Food and Pharma,Department of Process and Life Science Engineering,Departments at LTH,Faculty of Engineering, LTH,Lund University, Sweden(Swepub:lu)inl-mny
(author)
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Hållenius, FridaLund University,Lunds universitet,Avdelningen för livsmedel och läkemedel,Institutionen för processteknik och tillämpad biovetenskap,Institutioner vid LTH,Lunds Tekniska Högskola,Division of Food and Pharma,Department of Process and Life Science Engineering,Departments at LTH,Faculty of Engineering, LTH,Lund University, Sweden(Swepub:lu)cob-ffa
(author)
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Linnaeus UniversityInstitutionen för kemi och biomedicin (KOB)
(creator_code:org_t)
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In:Nutrients: MDPI AG14:52072-6643
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