Search: onr:"swepub:oai:lup.lub.lu.se:f7145c23-ede9-4d6b-ab85-90e71859726f" > AURKA F31I polymorp...
Fältnamn | Indikatorer | Metadata |
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000 | 06201naa a2201129 4500 | |
001 | oai:lup.lub.lu.se:f7145c23-ede9-4d6b-ab85-90e71859726f | |
003 | SwePub | |
008 | 160401s2007 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/6928092 URI |
024 | 7 | a https://doi.org/10.1158/1055-9965.EPI-07-01292 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Couch, Fergus J.4 aut |
245 | 1 0 | a AURKA F31I polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers: A consortium of investigators of modifiers of BRCA1/2 study |
264 | 1 | c 2007 |
520 | a The AURKA oncogene is associated with abnormal chromosome segregation and aneuploidy and predisposition to cancer. Amplification of AURKA has been detected at higher frequency in tumors from BRCA1 and BRCA2 mutation carriers than in sporadic breast tumors, suggesting that overexpression of AURKA and inactivation of BRCA1 and BRCA2 cooperate during tumor development and progression. The F31I polymorphism in AURKA has been associated with breast cancer risk in the homozygous state in prior studies. We evaluated whether the AURKA F31I polymorphism modifies breast cancer risk in BRCA1 and BRCA2 mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2. Consortium of Investigators of Modifiers of BRCA1/2 was established to provide sufficient statistical power through increased numbers of mutation carriers to identify polymorphisms that act as modifiers of cancer risk and can refine breast cancer risk estimates in BRCA1 and BRCA2 mutation carriers. A total of 4,935 BRCA1 and 2,241 BRCA2 mutation carriers and 11 individuals carrying both BRCA1 and BRCA2 mutations was genotyped for F31I. Overall, homozygosity for the 311 allele was not significantly associated with breast cancer risk in BRCA1 and BRCA2 carriers combined [hazard ratio (HR), 0.91; 95% confidence interval (95% CI), 0.77-1.061. Similarly, no significant association was seen in BRCA1 (HR, 0.90; 95% Cl, 0.75-1.08) or BRCA2 carriers (HR, 0.93; 95% CI, 0.67-1.29) or when assessing the modifying effects of either bilateral prophylactic oophorectomy or menopausal status of BRCA1 and BRCA2 carriers. In summary, the F31I polymorphism in AURKA is not associated with a modified risk of breast cancer in BRCA1 and BRCA2 carriers. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Sinilnikova, Olga4 aut |
700 | 1 | a Vierkant, Robert A.4 aut |
700 | 1 | a Pankratz, V. Shane4 aut |
700 | 1 | a Fredericksen, Zachary S.4 aut |
700 | 1 | a Stoppa-Lyonnet, Dominique4 aut |
700 | 1 | a Coupier, Isabelle4 aut |
700 | 1 | a Hughes, David4 aut |
700 | 1 | a Hardouin, Agnes4 aut |
700 | 1 | a Berthet, Pascaline4 aut |
700 | 1 | a Peock, Susan4 aut |
700 | 1 | a Cook, Margaret4 aut |
700 | 1 | a Baynes, Caroline4 aut |
700 | 1 | a Hodgson, Shirley4 aut |
700 | 1 | a Morrison, Patrick J.4 aut |
700 | 1 | a Porteous, Mary E.4 aut |
700 | 1 | a Jakubowska, Anna4 aut |
700 | 1 | a Lubinski, Jan4 aut |
700 | 1 | a Gronwald, Jacek4 aut |
700 | 1 | a Spurdle, Amanda B.4 aut |
700 | 1 | a kConFab, [unknown]4 aut |
700 | 1 | a Schmutzler, Rita4 aut |
700 | 1 | a Versmold, Beatrix4 aut |
700 | 1 | a Engel, Christoph4 aut |
700 | 1 | a Meindl, Alfons4 aut |
700 | 1 | a Sutter, Christian4 aut |
700 | 1 | a Horst, Jurgen4 aut |
700 | 1 | a Schaefer, Dieter4 aut |
700 | 1 | a Offit, Kenneth4 aut |
700 | 1 | a Kirchhoff, Tomas4 aut |
700 | 1 | a Andrulis, Irene L.4 aut |
700 | 1 | a Ilyushik, Eduard4 aut |
700 | 1 | a Glendon, Gordon4 aut |
700 | 1 | a Devilee, Peter4 aut |
700 | 1 | a Vreeswijk, Maaike P. G.4 aut |
700 | 1 | a Vasen, Hans F. A.4 aut |
700 | 1 | a Borg, Åkeu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-abo |
700 | 1 | a Harbst, Katjau Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-kbn |
700 | 1 | a Struewing, Jeffery P.4 aut |
700 | 1 | a Greene, Mark H.4 aut |
700 | 1 | a Neuhausen, Susan L.4 aut |
700 | 1 | a Rebbeck, Timothy R.4 aut |
700 | 1 | a Nathanson, Katherine4 aut |
700 | 1 | a Domchek, Susan4 aut |
700 | 1 | a Wagner, Theresa4 aut |
700 | 1 | a Garber, Judy E.4 aut |
700 | 1 | a Szabo, Csilla4 aut |
700 | 1 | a Zikan, Michal4 aut |
700 | 1 | a Foretova, Lenka4 aut |
700 | 1 | a Olson, Janet E.4 aut |
700 | 1 | a Sellers, Thomas A.4 aut |
700 | 1 | a Lindor, Noralane4 aut |
700 | 1 | a Ll, Heli Nevanlinna4 aut |
700 | 1 | a Tommiska, Johanna4 aut |
700 | 1 | a Aittomaki, Kristiina4 aut |
700 | 1 | a Hamann, Ute4 aut |
700 | 1 | a Rashid, Muhammad U.4 aut |
700 | 1 | a Torres, Diana4 aut |
700 | 1 | a Simard, Jacques4 aut |
700 | 1 | a Durocher, Francine4 aut |
700 | 1 | a Guenard, Frederic4 aut |
700 | 1 | a Lynch, Henry T.4 aut |
700 | 1 | a Isaacs, Claudine4 aut |
700 | 1 | a Weitzel, Jeffrey4 aut |
700 | 1 | a Olopade, Olufunmilayo I.4 aut |
700 | 1 | a Narod, Steven4 aut |
700 | 1 | a Daly, Mary B.4 aut |
700 | 1 | a Godwin, Andrew K.4 aut |
700 | 1 | a Tomlinson, Gail4 aut |
700 | 1 | a Easton, Douglas F.4 aut |
700 | 1 | a Chenevix-Trench, Georgia4 aut |
700 | 1 | a Antoniou, Antonis C.4 aut |
710 | 2 | a Bröstcancer-genetikb Sektion I4 org |
773 | 0 | t Cancer Epidemiology Biomarkers & Preventiong 16:7, s. 1416-1421q 16:7<1416-1421x 1538-7755 |
856 | 4 | u http://dx.doi.org/10.1158/1055-9965.EPI-07-0129x freey FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/692809 |
856 | 4 8 | u https://doi.org/10.1158/1055-9965.EPI-07-0129 |
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