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Genetic determinant...
Genetic determinants of glucose levels in pregnancy : Genetic risk scores analysis and GWAS in the Norwegian STORK cohort
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- Moen, Gunn Helen (author)
- University of Oslo,Oslo university hospital
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- LeBlanc, Marissa (author)
- Oslo university hospital
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- Sommer, Christine (author)
- Oslo university hospital
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- Prasad, Rashmi B. (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Lekva, Tove (author)
- Oslo university hospital
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- Normann, Kjersti R. (author)
- Oslo university hospital,University of Oslo
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- Qvigstad, Elisabeth (author)
- Oslo university hospital
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- Groop, Leif (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki,Institute for Molecular Medicine Finland (FIMM)
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- Birkeland, Kåre I. (author)
- Oslo university hospital,University of Oslo
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- Evans, David M. (author)
- University of Queensland,University of Bristol
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- Frøslie, Kathrine F. (author)
- Norwegian National Advisory Unit on Women's Health
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(creator_code:org_t)
- 2018
- 2018
- English 10 s.
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In: European Journal of Endocrinology. - 0804-4643. ; 179:6, s. 363-372
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Objective: Hyperglycaemia during pregnancy increases the risk of adverse health outcomes in mother and child, but the genetic aetiology is scarcely studied. Our aims were to (1) assess the overlapping genetic aetiology between the pregnant and non-pregnant population and (2) assess the importance of genome-wide polygenic contributions to glucose traits during pregnancy, by exploring whether genetic risk scores (GRSs) for fasting glucose (FG), 2-h glucose (2hG), type 2 diabetes (T2D) and BMI in non-pregnant individuals were associated with glucose measures in pregnant women. Methods: We genotyped 529 Norwegian pregnant women and constructed GRS from known genome-wide significant variants and SNPs weakly associated (p>5×10−8) with FG, 2hG, BMI and T2D from external genome-wide association studies (GWAS) and examined the association between these scores and glucose measures at gestational weeks 14-16 and 30-32. We also performed GWAS of FG, 2hG and shape information from the glucose curve during an oral glucose tolerance test (OGTT). Results: GRSFG explained similar variance during pregnancy as in the non-pregnant population (~5%). GRSBMI and GRST2D explained up to 1.3% of the variation in the glucose traits in pregnancy. If we included variants more weakly associated with these traits, GRS2hG and GRST2D explained up to 2.4% of the variation in the glucose traits in pregnancy, highlighting the importance of polygenic contributions. Conclusions: Our results suggest overlap in the genetic aetiology of FG in pregnant and non-pregnant individuals. This was less apparent with 2hG, suggesting potential differences in postprandial glucose metabolism inside and outside of pregnancy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Moen, Gunn Helen
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LeBlanc, Marissa
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Sommer, Christin ...
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Prasad, Rashmi B ...
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Lekva, Tove
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Normann, Kjersti ...
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show more...
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Qvigstad, Elisab ...
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Groop, Leif
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Birkeland, Kåre ...
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Evans, David M.
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Frøslie, Kathrin ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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European Journal ...
- By the university
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Lund University