Search: onr:"swepub:oai:lup.lub.lu.se:f7ae0c0f-a307-4ae6-8fee-cd778e3b8c09" >
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Gonçalves, IsabelLund University,Lunds universitet,Kardiovaskulär forskning - translationella studier,Forskargrupper vid Lunds universitet,Cardiovascular Research - Translational Studies,Lund University Research Groups
(author)
Association between renin and atherosclerotic burden in subjects with and without type 2 diabetes
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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2016-09-05
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Springer Science and Business Media LLC,2016
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10 s.
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LIBRIS-ID:oai:lup.lub.lu.se:f7ae0c0f-a307-4ae6-8fee-cd778e3b8c09
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https://lup.lub.lu.se/record/f7ae0c0f-a307-4ae6-8fee-cd778e3b8c09URI
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https://doi.org/10.1186/s12872-016-0346-8DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Background: Activation of the renin-angiotensin-aldosterone-system (RAAS) has been proposed to contribute to development of vascular complications in type 2 diabetes (T2D). The aim of the present study was to determine if plasma renin levels are associated with the severity of vascular changes in subjects with and without T2D. Methods: Renin was analyzed by the Proximity Extension Assay in subjects with (n = 985) and without (n = 515) T2D participating in the SUMMIT (SUrrogate markers for Micro- and Macro-vascular hard endpoints for Innovative diabetes Tools) study and in 205 carotid endarterectomy patients. Vascular changes were assessed by determining ankle-brachial pressure index (ABPI), carotid intima-media thickness (IMT), carotid plaque area, pulse wave velocity (PWV) and the reactivity hyperemia index (RHI). Results: Plasma renin was elevated in subjects with T2D and demonstrated risk factor-independent association with prevalent cardiovascular disease both in subjects with and without T2D. Renin levels increased with age, body mass index, HbA1c and correlated inversely with HDL. Subjects with T2D had more severe carotid disease, increased arterial stiffness, and impaired endothelial function. Risk factor-independent associations between renin and APBI, bulb IMT, carotid plaque area were observed in both T2D and non-T2D subjects. These associations were independent of treatment with RAAS inhibitors. Only weak associations existed between plasma renin and the expression of pro-inflammatory and fibrous components in plaques from 205 endarterectomy patients. Conclusions: Our findings provide clinical evidence for associations between systemic RAAS activation and atherosclerotic burden and suggest that this association is of particular importance in T2D.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Edsfeldt, AndreasLund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups(Swepub:lu)med-aet
(author)
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Colhoun, Helen M.University of Dundee
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Shore, Angela C.University of Exeter
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Palombo, CarloUniversity of Pisa
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Natali, AndreaUniversity of Pisa
(author)
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Fredrikson, Gunilla NordinLund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups(Swepub:lu)medf-gno
(author)
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Björkbacka, HarryLund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups(Swepub:lu)medf-hbj
(author)
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Wigren, MariaLund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups(Swepub:lu)med-mbr
(author)
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Bengtsson, EvaLund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups(Swepub:lu)medf-eb0
(author)
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Östling, GerdLund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups(Swepub:lu)medf-gos
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Aizawa, KunihikoUniversity of Exeter
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Casanova, FrancescoUniversity of Exeter
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Persson, MargarethaLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-mpe
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Gooding, KimUniversity of Exeter
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Gates, PhilUniversity of Exeter
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Khan, FaiselNinewells Hospital and Medical School
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Looker, Helen C.Ninewells Hospital and Medical School
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Adams, FionaNinewells Hospital and Medical School
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Belch, JillNinewells Hospital and Medical School
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Pinnola, SilviaUniversity of Pisa
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Venturi, ElenaUniversity of Pisa
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Kozakova, MichaelaUniversity of Pisa
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Gan, Li MingAstraZeneca, Sweden
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Schnecke, VolkerAstraZeneca, Sweden
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Nilsson, JanLund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups(Swepub:lu)medf-jni
(author)
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Kardiovaskulär forskning - translationella studierForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:BMC Cardiovascular Disorders: Springer Science and Business Media LLC16:1, s. 1-101471-2261
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Gonçalves, Isabe ...
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Edsfeldt, Andrea ...
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Colhoun, Helen M ...
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Shore, Angela C.
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Palombo, Carlo
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Natali, Andrea
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Fredrikson, Guni ...
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Björkbacka, Harr ...
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Wigren, Maria
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Östling, Gerd
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Aizawa, Kunihiko
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Casanova, France ...
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Persson, Margare ...
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Gooding, Kim
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Gates, Phil
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Khan, Faisel
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Looker, Helen C.
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Adams, Fiona
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Belch, Jill
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Pinnola, Silvia
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Venturi, Elena
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Gan, Li Ming
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