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Routine revasculari...
Routine revascularization with percutaneous coronary intervention in patients with coronary artery disease undergoing transcatheter aortic valve implantation – the third nordic aortic valve intervention trial – NOTION-3
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- Sabbah, Muhammad (author)
- Copenhagen University Hospital
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- Veien, Karsten (author)
- Odense University Hospital
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- Niemela, Matti (author)
- Oulu University Hospital
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- Freeman, Phillip (author)
- Aalborg University Hospital
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- Linder, Rickard (author)
- Karolinska Institutet,Karolinska Institute,Danderyd Hospital
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- Ioanes, Dan (author)
- Sahlgrenska University Hospital
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- Terkelsen, Christian Juhl (author)
- Aarhus University Hospital,Danish Heart Foundation
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- Kajander, Olli A. (author)
- Helsinki University Central Hospital,University of Helsinki
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- Koul, Sasha (author)
- Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital
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- Savontaus, Mikko (author)
- Turku University Hospital
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- Karjalainen, Pasi (author)
- University of Helsinki,Helsinki University Central Hospital
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- Erglis, Andrejs (author)
- University of Latvia
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- Minkkinen, Mikko (author)
- Helsinki University Central Hospital,University of Helsinki
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- Jørgensen, Troels (author)
- Copenhagen University Hospital
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- Sondergaard, Lars (author)
- Copenhagen University Hospital,University of Copenhagen
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- De Backer, Ole (author)
- Copenhagen University Hospital
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- Engstrøm, Thomas (author)
- Copenhagen University Hospital,University of Copenhagen
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- Lønborg, Jacob (author)
- Copenhagen University Hospital
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- English 13 s.
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In: American Heart Journal. - : Elsevier BV. - 0002-8703 .- 1097-6744. ; 255, s. 39-51
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Abstract
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- Background: Coronary artery disease (CAD) frequently coexists with severe aortic valve stenosis (AS) in patients planned for transcatheter aortic valve implantation (TAVI). How to manage CAD in this patient population is still an unresolved question. In particular, it is still not known whether fractional flow reserve (FFR) guided revascularization with percutaneous coronary intervention (PCI) is superior to medical treatment for CAD in terms of clinical outcomes. Study design: The third Nordic Aortic Valve Intervention (NOTION-3) Trial is an open-label investigator-initiated, multicenter multinational trial planned to randomize 452 patients with severe AS and significant CAD to either FFR-guided PCI or medical treatment, in addition to TAVI. Patients are eligible for the study in the presence of at least 1 significant PCI-eligible coronary stenosis. A significant stenosis is defined as either FFR ≤0.80 and/or diameter stenosis >90%. The primary end point is a composite of first occurring all-cause mortality, myocardial infarction, or urgent revascularization (PCI or coronary artery bypass graft performed during unplanned hospital admission) until the last included patient have been followed for 1 year after the TAVI. NOTION-3 is a multicenter, multinational randomized trial aiming at comparing FFR-guided revascularization vs medical treatment of CAD in patients with severe AS planned for TAVI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Sabbah, Muhammad
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Veien, Karsten
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Niemela, Matti
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Freeman, Phillip
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Linder, Rickard
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Ioanes, Dan
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show more...
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Terkelsen, Chris ...
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Kajander, Olli A ...
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Koul, Sasha
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Savontaus, Mikko
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Karjalainen, Pas ...
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Erglis, Andrejs
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Minkkinen, Mikko
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Jørgensen, Troel ...
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Sondergaard, Lar ...
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De Backer, Ole
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Engstrøm, Thomas
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Lønborg, Jacob
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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American Heart J ...
- By the university
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Lund University
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Karolinska Institutet