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C4b-binding protein (C4BP) activates B cells through the CD40 receptor
- Brodeur, SR (author)
- Angelini, F (author)
- Bacharier, LB (author)
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- Mizoguchi, E (author)
- Fujiwara, H (author)
- Plebani, A (author)
- Notarangelo, LD (author)
- Tsitsikov, E (author)
- Geha, RS (author)
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- (creator_code:org_t)
- 2003
- 2003
- English.
- In: Immunity. - 1074-7613. ; 18:6, s. 837-848
- Journal article (peer-reviewed)
Abstract
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- We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
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- By the author/editor
- Brodeur, SR
- Angelini, F
- Bacharier, LB
- Blom, Anna
- Mizoguchi, E
- Fujiwara, H
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- Plebani, A
- Notarangelo, LD
- Dahlbäck, Björn
- Tsitsikov, E
- Geha, RS
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Immunology in th ...
- Articles in the publication
- Immunity
- By the university
- Lund University
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