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Clinical determinan...
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Carreira, Patricia E.12 de Octubre University Hospital
(author)
Clinical determinants of elevated systolic pulmonary artery pressure measured by transthoracic Doppler echocardiography in early systemic sclerosis
- Article/chapterEnglish2017
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LIBRIS-ID:oai:lup.lub.lu.se:f8f1aa63-89dc-4892-a43f-40c077da6235
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https://lup.lub.lu.se/record/f8f1aa63-89dc-4892-a43f-40c077da6235URI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Objective. To explore the prevalence and clinical associations of elevated systolic pulmonary artery pressure (sPAP), measured by Transthoracic Dopplerechocardiography (TTE) in patients with early systemic sclerosis (SSc). Methods. A cross-sectional analysis of the prospective EULAR Scleroderma Trial and Research (EUSTAR) database was performed. SSc patients with < 3 years from the first non-Raynaud's phenomenon (RP) symptom at baseline EUSTAR visit, were selected. Elevated sPAP was defined as sPAP > 40 mmHg on baseline TTE. First visit SSc related variables, including disease subsets, antibodies and visceral involvement, were examined. Results. From 1,188 patients, 81% were women. Mean (SD) age at first non-RP symptom was 50 (14) years, 55% had limited cutaneous SSc (lcSSc) and 42% active disease. Elevated sPAP was found in 17% of patients, both lcSSc and diffuse cutaneous SSc (dc- SSc). In lcSSc, older age at first non- RP symptom, ACA positivity, joint contractures, restrictive defect and lower DLCO, were independently associated with elevated sPAP. In dcSSc, older age at first non-RP symptom, longer time between RP onset and first non-RP symptom, digital ulcers, cardiac blocks, and proteinuria were associated with elevated sPAP. Conclusion. The prevalence of elevated sPAP on TTE in early SSc patients is considerable. Association with cardiac, lung and renal involvement suggests that, although some patients might have pulmonary arterial hypertension, others may present pulmonary hypertension secondary to lung or heart involvement. Our findings emphasise the need to consider right heart catheterisation in selected early SSc patients with PH suspicion, to clearly determine the cause of PH.
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Carmona, LoretoInstituto de Salud Musculoesquelética (InMusc)
(author)
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Joven, Beatriz E.12 de Octubre University Hospital
(author)
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Loza, EstibalizInstituto de Salud Musculoesquelética (InMusc)
(author)
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Andreu, José LuisUniversity Hospital Puerta de Hierro
(author)
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Riemekasten, GabrielaUniversity of Lübeck
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Vettori, SerenaUniversity of Campania Luigi Vanvitelli
(author)
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Allanore, YannickParis Descartes University
(author)
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Balbir-Gurman, AlexandraTechnion - Israel Institute of Technology
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Airò, PaoloSpedali Civili Di Brescia
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Walker, Ulrich A.University Hospital Basel
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Damjanov, NemanjaUniversity of Belgrade
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Ananieva, Lidia P.Russian Academy of Medical Science
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Rednic, SimonaUniversity of Medicine and Pharmacy, Cluj-Napoca
(author)
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Czirják, LászlóUniversity of Pécs
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Distler, OliverUniversity Hospital of Zurich
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Farge, DominiqueSaint-Louis Hospital, Paris
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Hesselstrand, RogerLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-rhe
(author)
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Corrado, AdaUniversity of Foggia
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Caramaschi, PaolaUniversity Hospital Verona
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Tikly, MohammedUniversity of the Witwatersrand
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Matucci-Cerinic, MarcoUniversity of Florence
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12 de Octubre University HospitalInstituto de Salud Musculoesquelética (InMusc)
(creator_code:org_t)
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In:Clinical and Experimental Rheumatology35, s. 114-1210392-856X
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Carreira, Patric ...
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Carmona, Loreto
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Joven, Beatriz E ...
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Loza, Estibaliz
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Andreu, José Lui ...
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Riemekasten, Gab ...
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Vettori, Serena
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Allanore, Yannic ...
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Balbir-Gurman, A ...
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Airò, Paolo
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Walker, Ulrich A ...
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Damjanov, Nemanj ...
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Ananieva, Lidia ...
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Rednic, Simona
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Czirják, László
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Distler, Oliver
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Farge, Dominique
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Hesselstrand, Ro ...
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Corrado, Ada
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Caramaschi, Paol ...
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Tikly, Mohammed
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Matucci-Cerinic, ...
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