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- Feng, Yue HuaThird Affiliated Hospital of Soochow University (author)
Increased apolipoprotein M induced by lack of scavenger receptor BI is not activated via HDL-mediated cholesterol uptake in hepatocytes
- Article/chapterEnglish2018
Publisher, publication year, extent ...
- 2018-08-25
- Springer Science and Business Media LLC,2018
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- LIBRIS-ID:oai:lup.lub.lu.se:f9369af9-0578-401b-9993-838e50ce3744
- https://lup.lub.lu.se/record/f9369af9-0578-401b-9993-838e50ce3744URI
- https://doi.org/10.1186/s12944-018-0849-7DOI
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- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Background: Scavenger receptor BI (SR-BI) is a classic high-density lipoprotein (HDL) receptor, which mediates selective lipid uptake from HDL cholesterol esters (HDL-C). Apolipoprotein M (ApoM), as a component of HDL particles, could influence preβ-HDL formation and cholesterol efflux. The aim of this study was to determine whether SR-BI deficiency influenced the expression of ApoM. Methods: Blood samples and liver tissues were collected from SR-BI gene knockout mice, and serum lipid parameters, including total cholesterol (TC), triglyceride (TG), high and low-density lipoprotein cholesterol (HDL-C and LDL-C) and ApoM were measured. Hepatic ApoM and ApoAI mRNA levels were also determined. In addition, BLT-1, an inhibitor of SR-BI, was added to HepG2 cells cultured with cholesterol and HDL, under serum or serum-free conditions. The mRNA and protein expression levels of ApoM were detected by RT-PCR and western blot. Results: We found that increased serum ApoM protein levels corresponded with high hepatic ApoM mRNA levels in both male and female SR-BI-/- mice. Besides, serum TC and HDL-C were also significantly increased. Treatment of HepG2 hepatoma cells with SR-BI specific inhibitor, BLT-1, could up-regulate ApoM expression in serum-containing medium but not in serum-free medium, even in the presence of HDL-C and cholesterol. Conclusions: Results suggested that SR-BI deficiency promoted ApoM expression, but the increased ApoM might be independent from HDL-mediated cholesterol uptake in hepatocytes.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Läkemedelskemi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Medicinal Chemistry hsv//eng
- Apolipoprotein M
- Reverse cholesterol transport
- Scavenger receptor BI
- Selective cholesterol uptake
Added entries (persons, corporate bodies, meetings, titles ...)
- Zheng, LuThird Affiliated Hospital of Soochow University (author)
- Wei, JiangThird Affiliated Hospital of Soochow University (author)
- Yu, Miao MeiThird Affiliated Hospital of Soochow University (author)
- Zhang, JunThird Affiliated Hospital of Soochow University (author)
- Luo, Guang HuaThird Affiliated Hospital of Soochow University (author)
- Xu, NingLund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)kkem-nxu (author)
- Third Affiliated Hospital of Soochow UniversityAvdelningen för klinisk kemi och farmakologi (creator_code:org_t)
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- In:Lipids in Health and Disease: Springer Science and Business Media LLC17:11476-511X
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