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- Ekelund, MikaelLund University,Lunds universitet,Neurogastroenterologi,Forskargrupper vid Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurogastroenterology,Lund University Research Groups,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine (author)
Effects of total parenteral nutrition on rat enteric nervous system, intestinal morphology, and motility.
- Article/chapterEnglish2005
Publisher, publication year, extent ...
- Elsevier BV,2005
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- LIBRIS-ID:oai:lup.lub.lu.se:f9aa1556-7df9-4bf9-8496-be1feb0ea402
- https://lup.lub.lu.se/record/136281URI
- https://doi.org/10.1016/j.jss.2004.10.008DOI
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- Language:English
- Summary in:English
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- Total parenteral nutrition (TPN) is often crucial for patients not being able to feed enterally or having intestinal absorptive deficits. Enteral nutrition is, however, frequently regarded vital for maintaining functional and structural intestinal integrity. The aim of this study was to investigate possible effects of TPN on rat distal small intestine compared to enterally fed identically housed controls, regarding the enteric nervous system (ENS), motility in vitro, and morphology. This study shows that motor responses evoked by electrical stimulation or exposure to vasoactive intestinal peptide (VIP), pituitary adenylate cyclase activating peptide-27 (PACAP-27), and nitric oxide (NO) donor were unchanged. By using immunohistochemistry, the numbers of submucous (P < 0.05) and myenteric (P < 0.05) nerve cells were found to increase, expressed as numbers per unit length. The percentage of neurons expressing VIP, PACAP-27, NO-synthase, and galanin remained unchanged, however. By in situ hybridization the number of submucous neurons expressing neuropeptide Y-mRNA was found to decrease (P < 0.05); the other populations were unaltered. Morphometry revealed an increased submucosal thickness (P < 0.05), while intestinal circumference markedly decreased (P < 0.0001) in TPN-treated rats. In conclusion, TPN treatment resulted in reduced intestinal circumference leading to condensation of enteric neurons. No marked changes in neurotransmitter expression of the enteric neurons or in motor activity were noted.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
- plasticity
- motility
- morphology
- ENS
- intestine
- rat
- TPN
Added entries (persons, corporate bodies, meetings, titles ...)
- Ekelund, MatsLund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)kir-mek (author)
- Qader, SaleemLund University,Lunds universitet,Islet cell physiology,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)kir-sqa (author)
- Hallén, MagnusLund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)kir-mha (author)
- Ekblad, EvaLund University,Lunds universitet,Neurogastroenterologi,Forskargrupper vid Lunds universitet,Neurogastroenterology,Lund University Research Groups(Swepub:lu)mphy-eek (author)
- NeurogastroenterologiForskargrupper vid Lunds universitet (creator_code:org_t)
Related titles
- In:Journal of Surgical Research: Elsevier BV124:2, s. 187-1931095-86730022-4804
Internet link
- http://www.sciencedirect.com/science/article/pii/S0022480404006365FULLTEXT
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15820247&dopt=AbstractFULLTEXT
- http://dx.doi.org/10.1016/j.jss.2004.10.008FULLTEXT
- https://lup.lub.lu.se/record/136281
- https://doi.org/10.1016/j.jss.2004.10.008
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