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The discriminant po...
The discriminant power of bleeding history for the diagnosis of type 1 von Willebrand disease: an international, multicenter study
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Rodeghiero, F (author)
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Castaman, G (author)
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Tosetto, A (author)
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Batlle, J (author)
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Baudo, F (author)
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Cappelletti, A (author)
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Casana, P (author)
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De Bosch, N (author)
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Eikenboom, JCJ (author)
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Federici, AB (author)
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- Lethagen, Stefan (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Linari, S (author)
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Srivastava, A (author)
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(creator_code:org_t)
- Elsevier BV, 2005
- 2005
- English.
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In: Journal of Thrombosis and Haemostasis. - : Elsevier BV. - 1538-7933 .- 1538-7836. ; 3:12, s. 2619-2626
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Objective: The aim of this study was the validation of the criteria defining a significant mucocutaneous-bleeding history in type 1 von Willebrand disease (VWD). Subjects and methods: To avoid selection bias, 42 obligatory carriers (OC) of type 1 VWD were identified from a panel of 42 families with type 1 VWD enrolled by 10 expert centers. OC were identified by the presence of an offspring and another first degree relative with type 1 VWD (affected subjects, AFF). A standardized questionnaire was administered to evaluate hemorrhagic symptoms at the time of first examination, using a bleeding score ranging from 0 (no symptom) to 3 (hospitalization, replacement therapy, blood transfusion). Sensitivity, specificity, diagnostic likelihood ratios, positive and negative predictive values for the diagnosis of type 1 VWD were calculated from the data collected in OC and in 215 controls. Results: Having at least three hemorrhagic symptoms or a bleeding score of 3 in males and 5 in females was very specific (98.6%) for the bleeding history of type 1 VWD, although less sensitive (69.1%). None of the misclassified OC had life-threatening bleeding episodes after diagnosis. Conclusions: We suggest that the use of a standardized questionnaire and bleeding score may be useful for the identification of subjects requiring laboratory evaluation for VWD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- inherited bleeding disorders
- von Willebrand disease
- von Willebrand
- disease diagnosis
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Rodeghiero, F
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Castaman, G
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Tosetto, A
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Batlle, J
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Baudo, F
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Cappelletti, A
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show more...
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Casana, P
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De Bosch, N
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Eikenboom, JCJ
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Federici, AB
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Lethagen, Stefan
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Linari, S
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Srivastava, A
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Journal of Throm ...
- By the university
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Lund University