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Associations betwee...
Associations between APOE Genotypes and Disease Susceptibility, Joint Damage and Lipid Levels in Patients with Rheumatoid Arthritis
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Maehlen, Marthe T. (author)
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Provan, Sella A. (author)
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de Rooy, Diederik P. C. (author)
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van der Helm-van Mil, Annette H. M. (author)
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Krabben, Annemarie (author)
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- Saxne, Tore (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Lindqvist, Elisabet (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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Semb, Anne Grete (author)
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Uhlig, Till (author)
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van der Heijde, Desiree (author)
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Mero, Inger Lise (author)
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Olsen, Inge C. (author)
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Kvien, Tore K. (author)
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Lie, Benedicte A. (author)
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(creator_code:org_t)
- 2013-04-17
- 2013
- English.
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In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 8:4
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Abstract
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- Objective: Apolipoprotein E (APOE) genotypes are associated with cardiovascular disease (CVD) and lipid levels. In rheumatoid arthritis (RA), an association has been found with disease activity. We examined the associations between APOE genotypes and disease susceptibility and markers of disease severity in RA, including radiographic joint damage, inflammatory markers, lipid levels and cardiovascular markers. Method: A Norwegian cohort of 945 RA patients and 988 controls were genotyped for two APOE polymorphisms. We examined longitudinal associations between APOE genotypes and C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) as well as hand radiographs (van der Heijde Sharp Score(SHS)) in 207 patients with 10 year longitudinal data. Lipid levels, cardiovascular markers and history of CVD were compared across genotypes in a cross sectional study of 136 patients. Longitudinal radiological data of cohorts from Lund and Leiden were available for replication. (N = 935, with 4799 radiographs). Results: In the Norwegian cohort, associations between APOE genotypes and total cholesterol (TC) and low-density lipoproteins (LDL) were observed (epsilon 2
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Maehlen, Marthe ...
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Provan, Sella A.
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de Rooy, Diederi ...
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van der Helm-van ...
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Krabben, Annemar ...
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Saxne, Tore
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Lindqvist, Elisa ...
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Semb, Anne Grete
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Uhlig, Till
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van der Heijde, ...
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Mero, Inger Lise
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Olsen, Inge C.
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Kvien, Tore K.
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Lie, Benedicte A ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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PLoS ONE
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Lund University