Search: onr:"swepub:oai:lup.lub.lu.se:faec2925-abee-4bb5-bac4-9623c97f3fce" >
Genome-wide analysi...
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Shungin, DmitryUmeå universitet,Umeå University,Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;,Institutionen för odontologi
(author)
Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-06-24
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Springer Science and Business Media LLC,2019
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:faec2925-abee-4bb5-bac4-9623c97f3fce
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https://lup.lub.lu.se/record/faec2925-abee-4bb5-bac4-9623c97f3fceURI
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https://doi.org/10.1038/s41467-019-10630-1DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161588URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:141242177URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched for conserved genomic regions and partially overlapping with a range of complex traits including smoking, education, personality traits and metabolic measures. Using cardio-metabolic traits as an example in Mendelian randomization analysis, we estimate causal relationships and provide evidence suggesting that the processes contributing to dental caries may have undesirable downstream effects on health.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Haworth, SimonUniversity of Bristol
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Divaris, KimonUniversity of North Carolina
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Agler, Cary S.University of North Carolina,Osaka University
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Kamatani, YoichiroRIKEN Center for Integrative Medical Sciences
(author)
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Keun Lee, MyoungUniversity of Pittsburgh
(author)
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Grinde, KelseyUniversity of Washington
(author)
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Hindy, GeorgeLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)med-ghu
(author)
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Alaraudanjoki, ViiviUniversity of Oulu
(author)
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Pesonen, PaulaKarolinska Institutet
(author)
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Teumer, AlexanderUniversity Medicine Greifswald
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Holtfreter, BirteUniversity Medicine Greifswald
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Sakaue, SaoriOsaka University
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Hirata, JunOsaka University
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Yu, Yau HuaBrigham and Women's Hospital / Harvard Medical School,Tufts University
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Ridker, Paul M.Harvard University,Brigham and Women's Hospital / Harvard Medical School
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Giulianini, FrancoBrigham and Women's Hospital / Harvard Medical School
(author)
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Chasman, Daniel I.Brigham and Women's Hospital / Harvard Medical School,Harvard University
(author)
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Magnusson, Patrik K.E.Karolinska Institute
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Sudo, TakeakiTokyo Medical and Dental University
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Okada, YukinoriOsaka University
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Völker, UweUniversity Medicine Greifswald
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Kocher, ThomasUniversity Medicine Greifswald
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Anttonen, VuokkoUniversity of Oulu,Oulu University Hospital
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Laitala, Marja LiisaUniversity of Oulu
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Orho-Melander, MarjuLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)endo-mor
(author)
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Sofer, TamarBrigham and Women's Hospital / Harvard Medical School,Harvard University
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Shaffer, John R.University of Pittsburgh
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Vieira, AlexandreUniversity of Pittsburgh
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Marazita, Mary L.University of Pittsburgh
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Kubo, MichiakiRIKEN Center for Integrative Medical Sciences
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Furuichi, YasushiHokkaido University
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North, Kari E.University of North Carolina
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Offenbacher, SteveUniversity of North Carolina
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Ingelsson, ErikStanford University
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Franks, Paul W.Umeå universitet,Umeå University,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö SE-214 28, Sweden; Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA,Avdelningen för medicin(Swepub:umu)pafr0003
(author)
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Timpson, Nicholas J.University of Bristol
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Johansson, IngegerdUmeå universitet,Umeå University,Institutionen för odontologi(Swepub:umu)injo0003
(author)
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Umeå UniversityBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA;
(creator_code:org_t)
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In:Nature Communications: Springer Science and Business Media LLC10:12041-1723
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- By the author/editor
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Shungin, Dmitry
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Haworth, Simon
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Divaris, Kimon
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Agler, Cary S.
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Kamatani, Yoichi ...
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Keun Lee, Myoung
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show more...
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Grinde, Kelsey
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Hindy, George
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Alaraudanjoki, V ...
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Pesonen, Paula
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Teumer, Alexande ...
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Holtfreter, Birt ...
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Sakaue, Saori
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Hirata, Jun
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Yu, Yau Hua
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Ridker, Paul M.
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Giulianini, Fran ...
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Chasman, Daniel ...
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Magnusson, Patri ...
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Sudo, Takeaki
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Okada, Yukinori
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Völker, Uwe
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Kocher, Thomas
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Anttonen, Vuokko
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Laitala, Marja L ...
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Orho-Melander, M ...
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Sofer, Tamar
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Shaffer, John R.
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Vieira, Alexandr ...
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Marazita, Mary L ...
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Kubo, Michiaki
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Furuichi, Yasush ...
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North, Kari E.
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Offenbacher, Ste ...
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Ingelsson, Erik
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Franks, Paul W.
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Timpson, Nichola ...
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Johansson, Ingeg ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dentistry
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Nature Communica ...
- By the university
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Lund University
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Umeå University
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Karolinska Institutet