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Cross-Ancestry DNA ...
Cross-Ancestry DNA Methylation Marks of Insulin Resistance in Pregnancy : An Integrative Epigenome Wide Association Study
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- Fragoso-Bargas, N (author)
- Oslo university hospital
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- Elliott, H R (author)
- University of Bristol
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- Lee-Ødegård, S (author)
- University of Oslo
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- Opsahl, J O (author)
- University of Oslo
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- Sletner, L (author)
- Akershus University Hospital
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- Jenum, A K (author)
- University of Oslo
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- Drevon, Christian A (author)
- University of Oslo
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- Qvigstad, E (author)
- Oslo university hospital
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- Moen, G-H (author)
- Oslo university hospital
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- Birkeland, K I (author)
- Oslo university hospital
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- Prasad, R B (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki
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- Sommer, C (author)
- Oslo university hospital
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(creator_code:org_t)
- 2022-12-19
- 2023
- English.
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In: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 72:3, s. 415-426
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http://dx.doi.org/10...
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Abstract
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- Although there are some epigenome-wide association studies (EWAS) of insulin resistance, most of them did not replicate their findings and are focused in populations of European ancestry limiting the generalizability. In EPIPREG (294 Europeans and 162 South Asians), we conducted an EWAS of insulin resistance in maternal peripheral blood leukocytes, with replication in Born in Bradford (n=879; 430 Europeans and 449 South Asians), MENA (n=320) and Botnia (n=56) cohorts. In EPIPREG, we identified six CpG sites inversely associated with insulin resistance across ancestry, whereof five were replicated in independent cohorts (cg02988288, cg19693031, and cg26974062 in TXNIP, cg06690548 in SLC7A11, cg04861640 in ZSCAN26). From methylation quantitative trait loci analysis in EPIPREG, we identified gene variants related to all five replicated cross-ancestry CpG sites, which were associated with several cardiometabolic phenotypes. Mediation analyses suggested that the gene variants regulate insulin resistance through DNA methylation. To conclude, our cross-ancestry EWAS identified five CpG sites related with lower insulin resistance.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- art (subject category)
- ref (subject category)
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Diabetes
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- By the author/editor
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Fragoso-Bargas, ...
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Elliott, H R
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Lee-Ødegård, S
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Opsahl, J O
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Sletner, L
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Jenum, A K
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Drevon, Christia ...
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Qvigstad, E
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Moen, G-H
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Birkeland, K I
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Prasad, R B
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Sommer, C
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Diabetes
- By the university
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Lund University