Search: onr:"swepub:oai:lup.lub.lu.se:fb388517-8f06-4edb-b1ca-c25546be83ee" >
Interaction between...
Interaction between plasma phospholipid odd-chain fatty acids and GAD65 autoantibodies on the incidence of adult-onset diabetes : the EPIC-InterAct case–cohort study
-
- Lampousi, Anna Maria (author)
- Karolinska Institutet,Karolinska Institute,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
-
- Carlsson, Sofia (author)
- Karolinska Institutet,Karolinska Institute,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
-
- Löfvenborg, Josefin E. (author)
- Karolinska Institutet,Karolinska Institute,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Risk and Benefit Assessment, Swedish Food Agency, Uppsala, Sweden
-
show more...
-
- Cabrera-Castro, Natalia (author)
- Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain
-
- Chirlaque, María Dolores (author)
- Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Health and Social Sciences, Murcia University, Murcia, Spain,CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council
-
- Fagherazzi, Guy (author)
- Deep Digital Phenotyping Research Unit, Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg
-
- Franks, Paul W. (author)
- Umeå universitet,Umeå University,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Department of Clinical Sciences, Clinical Research Center, Skåne University Hospital, Lund University, Malmö, Sweden,Allmänmedicin
-
- Hampe, Christiane S. (author)
- Department of Medicine, University of Washington School of Medicine, WA, Seattle, United States
-
- Jakszyn, Paula (author)
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain; Blanquerna School of Health Sciences, Ramon Llull University, Barcelona, Spain,Catalan Institute of Oncology
-
- Koulman, Albert (author)
- Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom; National Institute for Health Research Biomedical Research Centre Core Nutritional Biomarker Laboratory, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
-
- Kyrø, Cecilie (author)
- Danish Cancer Society Research Center, Copenhagen, Denmark
-
- Moreno-Iribas, Conchi (author)
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain,CIBER Epidemiology and Public Health (CIBERESP)
-
- Nilsson, Peter M. (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Department of Clinical Sciences, Clinical Research Center, Skåne University Hospital, Lund University, Malmö, Sweden
-
- Panico, Salvatore (author)
- Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
-
- Papier, Keren (author)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
-
- van der Schouw, Yvonne T. (author)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
-
- Schulze, Matthias B. (author)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany,German Institute of Human Nutrition,German Center for Diabetes Research
-
- Weiderpass, Elisabete (author)
- International Agency for Research on Cancer, World Health Organization, Lyon, France
-
- Zamora-Ros, Raul (author)
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain
-
- Forouhi, Nita G. (author)
- Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
-
- Sharp, Stephen J. (author)
- Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
-
- Rolandsson, Olov (author)
- Umeå universitet,Umeå University,Allmänmedicin
-
- Wareham, Nicholas J. (author)
- Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
-
show less...
-
(creator_code:org_t)
- Springer Science+Business Media B.V. 2023
- 2023
- English 12 s.
-
In: Diabetologia. - : Springer Science+Business Media B.V.. - 0012-186X .- 1432-0428. ; 66:8, s. 1460-1471
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://doi.org/10.1...
-
https://umu.diva-por... (primary) (Raw object)
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
http://kipublication...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Aims/hypothesis: Islet autoimmunity may progress to adult-onset diabetes. We investigated whether circulating odd-chain fatty acids (OCFA) 15:0 and 17:0, which are inversely associated with type 2 diabetes, interact with autoantibodies against GAD65 (GAD65Ab) on the incidence of adult-onset diabetes. Methods: We used the European EPIC-InterAct case–cohort study including 11,124 incident adult-onset diabetes cases and a subcohort of 14,866 randomly selected individuals. Adjusted Prentice-weighted Cox regression estimated HRs and 95% CIs of diabetes in relation to 1 SD lower plasma phospholipid 15:0 and/or 17:0 concentrations or their main contributor, dairy intake, among GAD65Ab-negative and -positive individuals. Interactions between tertiles of OCFA and GAD65Ab status were estimated by proportion attributable to interaction (AP). Results: Low concentrations of OCFA, particularly 17:0, were associated with a higher incidence of adult-onset diabetes in both GAD65Ab-negative (HR 1.55 [95% CI 1.48, 1.64]) and GAD65Ab-positive (HR 1.69 [95% CI 1.34, 2.13]) individuals. The combination of low 17:0 and high GAD65Ab positivity vs high 17:0 and GAD65Ab negativity conferred an HR of 7.51 (95% CI 4.83, 11.69), with evidence of additive interaction (AP 0.25 [95% CI 0.05, 0.45]). Low dairy intake was not associated with diabetes incidence in either GAD65Ab-negative (HR 0.98 [95% CI 0.94, 1.02]) or GAD65Ab-positive individuals (HR 0.97 [95% CI 0.79, 1.18]). Conclusions/interpretation: Low plasma phospholipid 17:0 concentrations may promote the progression from GAD65Ab positivity to adult-onset diabetes. Graphical Abstract: [Figure not available: see fulltext.]
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Diabetes
- GAD65Ab
- Heptadecanoic
- Islet autoimmunity
- OCFA
- Pentadecanoic
- Diabetes
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Lampousi, Anna M ...
-
Carlsson, Sofia
-
Löfvenborg, Jose ...
-
Cabrera-Castro, ...
-
Chirlaque, María ...
-
Fagherazzi, Guy
-
show more...
-
Franks, Paul W.
-
Hampe, Christian ...
-
Jakszyn, Paula
-
Koulman, Albert
-
Kyrø, Cecilie
-
Moreno-Iribas, C ...
-
Nilsson, Peter M ...
-
Panico, Salvator ...
-
Papier, Keren
-
van der Schouw, ...
-
Schulze, Matthia ...
-
Weiderpass, Elis ...
-
Zamora-Ros, Raul
-
Forouhi, Nita G.
-
Sharp, Stephen J ...
-
Rolandsson, Olov
-
Wareham, Nichola ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
- Articles in the publication
-
Diabetologia
- By the university
-
Lund University
-
Karolinska Institutet
-
Umeå University