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PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells
- Eliasson, Lena (author)
-
- Renström, Erik (author)
- Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups
- Ammala, Carina (author)
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- Bokvist, Krister (author)
- Deeney, Jude T. (author)
- Flatt, Peter R. (author)
- Gabel, Jakob (author)
- Gromada, Jesper (author)
- Larsson, Olof (author)
- Lindstrom, Per (author)
- Rhodes, Christopher J. (author)
- Rorsman, Patrik (author)
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- (creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 1996
- 1996
- English.
- In: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 271:5250, s. 813-815
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Hypoglycemic sulfonylureas represent a group of clinically useful antidiabetic compounds that stimulate insulin secretion from pancreatic beta cells. The molecular mechanisms involved are not fully understood but are believed to involve inhibition of potassium channels sensitive to adenosine triphosphate (KATP channels) in the beta cell membrane, causing membrane depolarization, calcium influx, and activation of the secretory machinery. In addition to these effects, sulfonylureas also promoted exocytosis by direct interaction with the secretory machinery not involving closure of the plasma membrane KATP channels. This effect was dependent on protein kinase C (PKC) and was observed at therapeutic concentrations of sulfonylureas, which suggests that it contributes to their hypoglycemic action in diabetics.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- Rorsman, Patrik
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- Karolinska Institutet
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