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Attenuated early pr...
Attenuated early pregnancy weight gain by prenatal lifestyle interventions does not prevent gestational diabetes in the LIFE-Moms consortium
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- Redman, Leanne M. (author)
- Pennington Biomedical Research Center
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- Drews, Kimberly L. (author)
- George Washington University
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- Klein, Samuel (author)
- Washington University in St. Louis
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- Horn, Linda Van (author)
- Northwestern University
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- Wing, Rena R. (author)
- Brown University
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- Pi-Sunyer, Xavier (author)
- Columbia University
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- Evans, Mary (author)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Joshipura, Kaumudi (author)
- University of Puerto Rico,Harvard University
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- Arteaga, S. Sonia (author)
- National Heart Lung and Blood Institute,National Institutes of Health, United States
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- Cahill, Alison G. (author)
- University of Texas at Austin
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- Clifton, Rebecca G. (author)
- George Washington University
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- Couch, Kimberly A. (author)
- Phoenix Indian Medical Center
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- Franks, Paul W. (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University
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- Gallagher, Dympna (author)
- Columbia University
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- Haire-Joshu, Debra (author)
- Washington University in St. Louis
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- Martin, Corby K. (author)
- Pennington Biomedical Research Center
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- Peaceman, Alan M. (author)
- Northwestern University
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- Phelan, Suzanne (author)
- California Polytechnic State University
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- Thom, Elizabeth A. (author)
- George Washington University
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- Yanovski, Susan Z. (author)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Knowler, William C. (author)
- National Institute of Diabetes and Digestive and Kidney Diseases
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(creator_code:org_t)
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- Elsevier BV, 2021
- 2021
- English.
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In: Diabetes Research and Clinical Practice. - : Elsevier BV. - 0168-8227. ; 171
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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Abstract
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- Aims: To examine the effect of lifestyle (diet and physical activity) interventions on the prevalence of GDM, considering the method of GDM ascertainment and its association with early pregnancy characteristics and maternal and neonatal outcomes in the LIFE-Moms consortium. Methods: LIFE-Moms evaluated the effects of lifestyle interventions to optimize gestational weight gain in 1148 pregnant women with BMI ≥ 25 kg/m2 and without known diabetes at enrollment, compared with standard care. GDM was assessed between 24 and 31-weeks gestation by a 2-hour, 75-gram OGTT or by local clinical practice standards. Results: Lifestyle interventions initiated prior to 16 weeks reduced early excess GWG compared with standard care (0.35 ± 0.24 vs 0.43 ± 0.26 kg per week, p=<0.0001) but did not affect GDM diagnosis (11.1% vs 11.6%, p = 0.91). Using the 75-gram, 2-hour OGTT, 13. 0% of standard care and 11.0% of the intervention group had GDM by the IADPSG criteria (p = 0.45). The ‘type of diagnostic test’ did not change the result (p = 0.86). Women who developed GDM were significantly heavier, more likely to have obesity, and more likely to have dysglycemia at baseline. Conclusion: Moderate-to-high intensity lifestyle interventions grounded in behavior change theory initiated between 9 and 16-weeks gestation did not affect the prevalence of GDM despite reducing early GWG. Clinicaltrials.gov: NCT01545934, NCT01616147, NCT01771133, NCT01631747, NCT01768793, NCT01610752, NCT01812694.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Clinical trials
- Gestational diabetes mellitus
- Lifestyle modification
Publication and Content Type
- art (subject category)
- ref (subject category)
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Redman, Leanne M ...
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Drews, Kimberly ...
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Klein, Samuel
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Horn, Linda Van
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Wing, Rena R.
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Pi-Sunyer, Xavie ...
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show more...
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Evans, Mary
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Joshipura, Kaumu ...
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Arteaga, S. Soni ...
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Cahill, Alison G ...
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Clifton, Rebecca ...
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Couch, Kimberly ...
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Franks, Paul W.
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Gallagher, Dympn ...
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Haire-Joshu, Deb ...
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Martin, Corby K.
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Peaceman, Alan M ...
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Phelan, Suzanne
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Thom, Elizabeth ...
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Yanovski, Susan ...
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Knowler, William ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes Researc ...
- By the university
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Lund University