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Biomarkers Predicti...
Biomarkers Predictive of Atrial Fibrillation in Patients with Cryptogenic Stroke. Insights from The Nordic Atrial Fibrillation and Stroke (NOR-FIB) Study
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- Tancin Lambert, Anna (author)
- University of Oslo,Østfold Hospital
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- Ratajczak-Tretel, Barbara (author)
- Østfold Hospital
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- Al-Ani, Riadh (author)
- Østfold Hospital
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- Arntzen, Kathrine (author)
- Nordland Hospital Bodø
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- Bakkejord, Grete Kristin (author)
- Nordland Hospital Bodø
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- Bekkeseth, Hanna Marie Otterholt (author)
- Innlandet Hospital Trust
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- Bjerkeli, Vigdis (author)
- Oslo university hospital
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- Eldøen, Guttorm (author)
- Molde Hospital
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- Gulsvik, Anne Kristine (author)
- Diakonhjemmet Hospital
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- Halvorsen, Bente (author)
- Oslo university hospital
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- Høie, Gudrun Anette (author)
- Østfold Hospital
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- Ihle-Hansen, Hege (author)
- Oslo university hospital
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- Ihle-Hansen, Håkon (author)
- Baerum Hospital
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- Ingebrigtsen, Susanne (author)
- University Hospital of North Norway
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- Johansen, Henriette (author)
- Oslo university hospital
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- Kremer, Christine (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Krogseth, Siv Bohne (author)
- Vestfold Hospital
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- Kruuse, Christina (author)
- Gentofte Hospital
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- Kurz, Martin (author)
- Stavanger University Hospital
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- Nakstad, Ingvild (author)
- Drammen Hospital
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- Novotny, Vojtech (author)
- Haukeland University Hospital
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- Naess, Halvor (author)
- Haukeland University Hospital
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- Qazi, Rehman (author)
- Diakonhjemmet Hospital
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- Rezai, Mehdi Kallaj (author)
- Stavanger University Hospital
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- Rørholt, Dag Marius (author)
- Molde Hospital
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- Steffensen, Linn Hofsoy (author)
- University Hospital of North Norway
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- Sømark, Jesper (author)
- Innlandet Hospital Trust
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- Tobro, Håkon (author)
- Telemark Hospital
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- Truelsen, Thomas Clement (author)
- Copenhagen University Hospital
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- Wassvik, Lejla (author)
- Bispebjerg Hospital
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- AEgidius, Karen Lehrmann (author)
- Bispebjerg Hospital
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- Pesonen, Maiju (author)
- Oslo university hospital
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- de Melis, Mirko (author)
- Medtronic Bakken Research Center, Maastricht
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- Atar, Dan (author)
- Oslo university hospital
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- Aamodt, Anne Hege (author)
- Oslo university hospital
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(creator_code:org_t)
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- 2023-03-10
- 2023
- English.
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In: European Journal of Neurology. - : Wiley. - 1351-5101 .- 1468-1331. ; 30:5, s. 1352-1363
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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Abstract
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- BACKGROUND: There are currently no biomarkers used to select cryptogenic stroke (CS) patients for monitoring with insertable cardiac monitors (ICMs), the most effective tool for diagnosing atrial fibrillation (AF) in CS. The purpose of this study was to assess clinically available biomarkers as predictors of AF.METHODS: Eligible CS and cryptogenic transient ischemic attack (TIA) patients underwent 12-month monitoring with ICMs, clinical follow-up, and biomarker sampling. Levels of cardiac and thromboembolic biomarkers, taken within 14 days from symptom onset, were compared between patients diagnosed with AF (n=74) during monitoring and those without AF (n=185). Receiver operating characteristic (ROC) curves were created. Biomarkers reaching area under ROC curve (AUC) ≥ 0.7 were dichotomized by finding optimal cut-off values and used in logistic regression establishing their predictive value for increased risk of AF in unadjusted and adjusted models.RESULTS: B-type natriuretic peptide (BNP), N-terminal pro-brain natriuretic peptide (NT-proBNP), creatine kinase, D-dimer, high-sensitivity cardiac Troponin I and T were significantly higher in the AF than non-AF group. BNP and NT-proBNP reached predefined AUC level, 0.755 and 0.725 respectively. Optimal cut-off values were 33.5 ng/L for BNP, and 87 ng/L for NT-proBNP. Regression analysis showed that NT-proBNP was a predictor of AF in both unadjusted, odds ratio (OR) 7.72 (95% confidence interval [CI] 3.16-18.87), and age and sex adjusted models, OR 4.82 (95% CI 1.79-12.96).CONCLUSION: Several clinically established biomarkers were associated with AF. NT-proBNP performed best as AF predictor and could be used for selecting patients for long-term monitoring with ICMs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Tancin Lambert, ...
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Ratajczak-Tretel ...
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Al-Ani, Riadh
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Arntzen, Kathrin ...
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Bakkejord, Grete ...
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Bekkeseth, Hanna ...
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show more...
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Bjerkeli, Vigdis
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Eldøen, Guttorm
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Gulsvik, Anne Kr ...
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Halvorsen, Bente
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Høie, Gudrun Ane ...
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Ihle-Hansen, Heg ...
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Ihle-Hansen, Håk ...
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Ingebrigtsen, Su ...
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Johansen, Henrie ...
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Kremer, Christin ...
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Krogseth, Siv Bo ...
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Kruuse, Christin ...
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Kurz, Martin
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Nakstad, Ingvild
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Novotny, Vojtech
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Naess, Halvor
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Qazi, Rehman
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Rezai, Mehdi Kal ...
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Rørholt, Dag Mar ...
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Steffensen, Linn ...
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Sømark, Jesper
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Tobro, Håkon
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Truelsen, Thomas ...
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Wassvik, Lejla
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AEgidius, Karen ...
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Pesonen, Maiju
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de Melis, Mirko
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Atar, Dan
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Aamodt, Anne Heg ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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European Journal ...
- By the university
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Lund University