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Ehlén, ÅsaLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups
(author)
Tumors with non-functional RB1 are killed by reduced gamma-tubulin levels.
- Article/chapterEnglish2012
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LIBRIS-ID:oai:lup.lub.lu.se:fc9841d0-9d91-4af3-bd7a-5c6e365fd551
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https://lup.lub.lu.se/record/2519610URI
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https://doi.org/10.1074/jbc.M112.357038DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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In various tumors inactivation of growth control is achieved by interfering with the RB1 signaling pathway. Here, we describe that RB1 and γ tubulin proteins moderate each other's expression by binding to their respective gene promoters. Simultaneous reduction of RB1 and γ tubulin protein levels result in an E2F1-dependent upregulation of apoptotic genes such as caspase 3. We report that in various tumors types, there is an inverse correlation between the expression levels of γ tubulin and RB1 and that in tumor cell lines with a non-functioning RB1, reduction of γ tubulin protein levels leads to induction of apoptosis. Thus, the RB1/γ tubulin signal network can be considered as a new target for cancer treatment.
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Rossello Castillo, Catalina AnaLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups(Swepub:lu)med-crc
(author)
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von Stedingk, KristofferLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine(Swepub:lu)med-kvt
(author)
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Eklund, GretaLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups(Swepub:lu)med-geh
(author)
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Nilsson, EliseLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups(Swepub:lu)pat-eni
(author)
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Pettersson, HelenLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine(Swepub:lu)molm-hpe
(author)
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Jirström, KarinLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pat-kji
(author)
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Alvarado-Kristensson, MariaLund University,Lunds universitet,Molekylär patologi, Malmö,Forskargrupper vid Lunds universitet,Patologi, Malmö,Molecular Pathology, Malmö,Lund University Research Groups,Pathology, Malmö(Swepub:lu)expp-mkr
(author)
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Patologi, MalmöForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
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In:Journal of Biological Chemistry287:21, s. 17241-172471083-351X
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