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Association of chan...
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de las Heras Gala, ToniaGerman Center for Diabetes Research,Helmholtz Zentrum München
(author)
Association of changes in inflammation with variation in glycaemia, insulin resistance and secretion based on the KORA study
- Article/chapterEnglish2018
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LIBRIS-ID:oai:lup.lub.lu.se:fce6f9fa-bc98-486b-bd03-07775837df08
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https://lup.lub.lu.se/record/fce6f9fa-bc98-486b-bd03-07775837df08URI
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https://doi.org/10.1002/dmrr.3063DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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Aims: Subclinical systemic inflammation may contribute to the development of type 2 diabetes, but its association with early progression of glycaemic deterioration in persons without diabetes has not been fully investigated. Our primary aim was to assess longitudinal associations of changes in pro-inflammatory (leukocytes, high-sensitivity C-reactive protein (hsCRP)) and anti-inflammatory (adiponectin) markers with changes in markers that assessed glycaemia, insulin resistance, and secretion (HbA1c, HOMA-IR, and HOMA-ß). Furthermore, we aimed to directly compare longitudinal with cross-sectional associations. Materials and methods: This study includes 819 initially nondiabetic individuals with repeated measurements from the Cooperative Health Research in the Region of Augsburg (KORA) S4/F4 cohort study (median follow-up: 7.1 years). Longitudinal and cross-sectional associations were simultaneously examined using linear mixed growth models. Changes in markers of inflammation were used as independent and changes in markers of glycaemia/insulin resistance/insulin secretion as dependent variables. Models were adjusted for age, sex, major lifestyle and metabolic risk factors for diabetes using time-varying variables in the final model. Results: Changes of leukocyte count were positively associated with changes in HbA1c and HOMA-ß while changes in adiponectin were inversely associated with changes in HbA1c. All examined cross-sectional associations were statistically significant; they were generally stronger and mostly directionally consistent to the longitudinal association estimates. Conclusions: Adverse changes in low-grade systemic inflammation go along with glycaemic deterioration and increased insulin secretion independently of changes in other risk factors, suggesting that low-grade inflammation may contribute to the development of hyperglycaemia and a compensatory increase in insulin secretion.
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Herder, ChristianGerman Center for Diabetes Research,Heinrich Heine University Düsseldorf
(author)
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Rutters, FemkeAmsterdam UMC - Vrije Universiteit Amsterdam
(author)
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Carstensen-Kirberg, MarenHeinrich Heine University Düsseldorf,German Center for Diabetes Research
(author)
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Huth, CorneliaGerman Center for Diabetes Research,Helmholtz Zentrum München
(author)
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Stehouwer, Coen D.A.Maastricht University Medical Centre
(author)
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Nijpels, GielAmsterdam UMC - Vrije Universiteit Amsterdam
(author)
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Schalkwijk, CasperMaastricht University Medical Centre
(author)
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Flyvbjerg, AllanSteno Diabetes Center Copenhagen
(author)
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Franks, Paul W.Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-plf
(author)
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Dekker, JacquelineAmsterdam UMC - Vrije Universiteit Amsterdam
(author)
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Meisinger, ChristaLudwig-Maximilian University of Munich,Helmholtz Zentrum München,German Center for Diabetes Research
(author)
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Koenig, WolfgangUniversity of Ulm,Technical University of Munich,German Centre for Cardiovascular Research
(author)
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Roden, MichaelGerman Center for Diabetes Research,Heinrich Heine University Düsseldorf
(author)
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Rathmann, WolfgangGerman Center for Diabetes Research,Heinrich Heine University Düsseldorf
(author)
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Peters, AnnetteGerman Center for Diabetes Research,German Centre for Cardiovascular Research,Helmholtz Zentrum München
(author)
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Thorand, BarbaraHelmholtz Zentrum München,German Center for Diabetes Research
(author)
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German Center for Diabetes ResearchHelmholtz Zentrum München
(creator_code:org_t)
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IMI DIRECT Consortium
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In:Diabetes/Metabolism Research and Reviews: Wiley34:81520-7552
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Nijpels, Giel
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Koenig, Wolfgang
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