Search: onr:"swepub:oai:lup.lub.lu.se:fd4d7d72-baa3-4d29-b7ad-b1f04116d619" >
Transgenic expressi...
Transgenic expression of human cytokines in immunodeficient mice does not facilitate myeloid expansion of BCR-ABL1 transduced human cord blood cells
-
- Askmyr, Maria (author)
- Lund University,Lunds universitet,Translationella genomiska och funktionella studier av leukemi,Forskargrupper vid Lunds universitet,Translational Genomic and Functional Studies of Leukemia,Lund University Research Groups
-
- Von Palffy, Sofia (author)
- Lund University,Lunds universitet,Translationella genomiska och funktionella studier av leukemi,Forskargrupper vid Lunds universitet,Translational Genomic and Functional Studies of Leukemia,Lund University Research Groups
-
- Hansen, Nils (author)
- Lund University,Lunds universitet,Translationella genomiska och funktionella studier av leukemi,Forskargrupper vid Lunds universitet,Translational Genomic and Functional Studies of Leukemia,Lund University Research Groups
-
show more...
-
- Landberg, Niklas (author)
- Lund University,Lunds universitet,Translationella genomiska och funktionella studier av leukemi,Forskargrupper vid Lunds universitet,Translational Genomic and Functional Studies of Leukemia,Lund University Research Groups
-
- Högberg, Carl (author)
- Lund University,Lunds universitet,Translationella genomiska och funktionella studier av leukemi,Forskargrupper vid Lunds universitet,Translational Genomic and Functional Studies of Leukemia,Lund University Research Groups
-
- Rissler, Marianne (author)
- Lund University,Lunds universitet,Translationella genomiska och funktionella studier av leukemi,Forskargrupper vid Lunds universitet,Translational Genomic and Functional Studies of Leukemia,Lund University Research Groups
-
- Ågerstam, Helena (author)
- Lund University,Lunds universitet,Translationella genomiska och funktionella studier av leukemi,Forskargrupper vid Lunds universitet,Translational Genomic and Functional Studies of Leukemia,Lund University Research Groups
-
- Fioretos, Thoas (author)
- Lund University,Lunds universitet,Translationella genomiska och funktionella studier av leukemi,Forskargrupper vid Lunds universitet,Translational Genomic and Functional Studies of Leukemia,Lund University Research Groups,Regional Laboratories Region Skåne
-
show less...
-
(creator_code:org_t)
- 2017-10-12
- 2017
- English.
-
In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 12:10
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://journals.plo...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Several attempts have been made to model chronic myeloid leukemia (CML) in a xenograft setting but expansion of human myeloid cells in immunodeficient mice has proven difficult to achieve. Lack of cross-reacting cytokines in the microenvironment of the mice has been proposed as a potential reason. In this study we have used NOD/SCID IL2–receptor gamma deficient mice expressing human SCF, IL-3 and GM-CSF (NSGS mice), that should be superior in supporting human, and particularly, myeloid cell engraftment, to expand BCR-ABL1 expressing human cells in order to model CML. NSGS mice transplanted with BCR-ABL1 expressing cells became anemic and had to be sacrificed due to illness, however, this was not accompanied by an expansion of human myeloid cells but rather we observed a massive expansion of human T-cells and macrophages/histiocytes. Importantly, control human cells without BCR-ABL1 expression elicited a similar reaction, although with a slight delay of disease induction, suggesting that while BCR-ABL1 contributes to the inflammatory reaction, the presence of normal human hematopoietic cells is detrimental for NSGS mice.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
-
PLoS ONE
(Search for host publication in LIBRIS)
To the university's database