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Head-to-head compar...
Head-to-head comparison of amplified plasmonic exosome Aβ42 platform and single-molecule array immunoassay in a memory clinic cohort
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- Tanaka, Tomotaka (author)
- National University of Singapore,National Cerebral and Cardiovascular Center
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- Ruifen, Joyce Chong (author)
- National University of Singapore
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- Nai, Ying Hwey (author)
- National University of Singapore
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- Tan, Chin Hong (author)
- Nanyang Technological University,National University of Singapore
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- Lim, Carine Z.J. (author)
- National University of Singapore
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- Zhang, Yan (author)
- National University of Singapore
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- Stephenson, Mary C. (author)
- National University of Singapore
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- Hilal, Saima (author)
- National University of Singapore
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- Saridin, Francis N. (author)
- National University of Singapore
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- Gyanwali, Bibek (author)
- National University of Singapore
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- Villaraza, Steven (author)
- National University of Singapore
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- Robins, Edward G. (author)
- A*Star Singapore Bio-Imaging Consortium (SBIC),National University of Singapore
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- Ihara, Masafumi (author)
- National Cerebral and Cardiovascular Center
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- Schöll, Michael (author)
- Gothenburg University,Göteborgs universitet,Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,University College London,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Ashton, Nicholas J. (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,South London and Maudsley NHS Foundation Trust,King's College London,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Shao, Huilin (author)
- National University of Singapore
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- Reilhac, Anthonin (author)
- National University of Singapore
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- Chen, Christopher (author)
- National University of Singapore
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(creator_code:org_t)
- 2021-01-23
- 2021
- English 11 s.
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In: European Journal of Neurology. - : Wiley. - 1351-5101 .- 1468-1331. ; 28:5, s. 1479-1489
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Abstract
Subject headings
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- Background and purpose: Various blood biomarkers reflecting brain amyloid-β (Aβ) load have recently been proposed with promising results. However, to date, no comparative study amongst blood biomarkers has been reported. Our objective was to examine the diagnostic performance and cost effectiveness of three blood biomarkers on the same cohort. Methods: Using the same cohort (n = 68), the performances of the single-molecule array (Simoa) Aβ40, Aβ42, Aβ42/Aβ40 and the amplified plasmonic exosome (APEX) Aβ42 blood biomarkers were compared using amyloid positron emission tomography (PET) as the reference standard. The extent to which these blood tests can reduce the recruitment cost of clinical trials was also determined by identifying amyloid positive (Aβ+) participants. Results: Compared to Simoa biomarkers, APEX-Aβ42 showed significantly higher correlations with amyloid PET retention values and excellent diagnostic performance (sensitivity 100%, specificity 93.3%, area under the curve 0.995). When utilized for clinical trial recruitment, our simulation showed that pre-screening with blood biomarkers followed by a confirmatory amyloid PET imaging would roughly half the cost (56.8% reduction for APEX-Aβ42 and 48.6% for Simoa-Aβ42/Aβ40) compared to the situation where only PET imaging is used. Moreover, with 100% sensitivity, APEX-Aβ42 pre-screening does not increase the required number of initial participants. Conclusions: With its high diagnostic performance, APEX is an ideal candidate for Aβ+ subject identification, monitoring and primary care screening, and could efficiently enrich clinical trials with Aβ+ participants whilst halving recruitment costs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer’s disease
- cost saving
- exosome
- plasma Aβ42/Aβ40 ratio
- Simoa
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Tanaka, Tomotaka
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Ruifen, Joyce Ch ...
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Nai, Ying Hwey
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Tan, Chin Hong
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Lim, Carine Z.J.
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Zhang, Yan
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show more...
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Stephenson, Mary ...
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Hilal, Saima
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Saridin, Francis ...
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Gyanwali, Bibek
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Villaraza, Steve ...
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Robins, Edward G ...
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Ihara, Masafumi
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Schöll, Michael
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Zetterberg, Henr ...
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Blennow, Kaj
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Ashton, Nicholas ...
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Shao, Huilin
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Reilhac, Anthoni ...
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Chen, Christophe ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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European Journal ...
- By the university
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Lund University
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University of Gothenburg