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Dramatic influence ...
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Bucciarelli, SaskiaLund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
(author)
Dramatic influence of patchy attractions on short-time protein diffusion under crowded conditions
- Article/chapterEnglish2016
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American Association for the Advancement of Science (AAAS),2016
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9 s.
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LIBRIS-ID:oai:lup.lub.lu.se:fefd8e86-f4f6-43dc-b416-cbfc1b9b8735
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https://lup.lub.lu.se/record/fefd8e86-f4f6-43dc-b416-cbfc1b9b8735URI
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https://doi.org/10.1126/sciadv.1601432DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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In the dense and crowded environment of the cell cytoplasm, an individual protein feels the presence of and interacts with all surrounding proteins. While we expect this to strongly influence the short-time diffusion coefficient Ds of proteins on length scales comparable to the nearest-neighbor distance, this quantity is difficult to assess experimentally. We demonstrate that quantitative information about Ds can be obtained from quasi-elastic neutron scattering experiments using the neutron spin echo technique. We choose two well-characterized and highly stable eye lens proteins, bovine α-crystallin and γB-crystallin, and measure their diffusion at concentrations comparable to those present in the eye lens. While diffusion slows down with increasing concentration for both proteins, we find marked variations that are directly linked to subtle differences in their interaction potentials. A comparison with computer simulations shows that anisotropic and patchy interactions play an essential role in determining the local short-time dynamics. Hence, our study clearly demonstrates the enormous effect that weak attractions can have on the short-time diffusion of proteins at concentrations comparable to those in the cellular cytosol.
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Myung, Jin SukLund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Jülich Research Centre(Swepub:lu)ji8662my
(author)
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Farago, BelaInstitut Laue Langevin
(author)
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Das, ShibanandaJülich Research Centre
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Vliegenthart, Gerard AJülich Research Centre
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Holderer, OlafJülich Research Centre
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Winkler, Roland G.Jülich Research Centre
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Schurtenberger, PeterLund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)fkem-psh
(author)
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Gompper, GerhardJülich Research Centre
(author)
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Stradner, AnnaLund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,University of Fribourg(Swepub:lu)fkem-aas
(author)
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Fysikalisk kemiEnheten för fysikalisk och teoretisk kemi
(creator_code:org_t)
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In:Science Advances: American Association for the Advancement of Science (AAAS)2:12, s. 1601432-16014322375-2548
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Bucciarelli, Sas ...
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Myung, Jin Suk
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Farago, Bela
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Das, Shibananda
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Vliegenthart, Ge ...
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Holderer, Olaf
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Winkler, Roland ...
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Schurtenberger, ...
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Gompper, Gerhard
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Stradner, Anna
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