Search: onr:"swepub:oai:lup.lub.lu.se:ff65d5ba-2257-4884-95d6-a02d1f0ef1f4" > Local expression of...
Fältnamn | Indikatorer | Metadata |
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000 | 04071naa a2200397 4500 | |
001 | oai:lup.lub.lu.se:ff65d5ba-2257-4884-95d6-a02d1f0ef1f4 | |
003 | SwePub | |
008 | 160401s2015 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/50397912 URI |
024 | 7 | a https://doi.org/10.1007/s00262-015-1658-82 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Okroj, Marcinu Lund University,Lunds universitet,Proteinkemi, Malmö,Forskargrupper vid Lunds universitet,Protein Chemistry, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)med-moj |
245 | 1 0 | a Local expression of complement factor I in breast cancer cells correlates with poor survival and recurrence. |
264 | c 2015-01-25 | |
264 | 1 | b Springer Science and Business Media LLC,c 2015 |
338 | a electronic2 rdacarrier | |
520 | a Tumor cells often evade killing by the complement system by overexpressing membrane-bound complement inhibitors. However, production of soluble complement inhibitors in cells other than hepatocytes was rarely reported. We screened several breast cancer cell lines for expression of soluble complement inhibitor, complement factor I (FI). We also analyzed local production of FI in tissue microarrays with tumors from 130 breast cancer patients by in situ hybridization and immunohistochemistry. We found expression of FI in breast adenocarcinoma cell line MDA-MB-468 and confirmed its functional activity. Expression of FI at mRNA and protein levels was also confirmed in tumor cells and tumor stroma, both in fibroblasts and infiltrating immune cells. Multivariate Cox regression analyses revealed that high expression of FI protein in tumor cells was correlated with significantly shorter cancer-specific survival (HR 2.8; 95 % CI 1.0-7.5; p = 0.048) and recurrence-free survival (HR 3.4; 95 % CI 1.5-7.4; p = 0.002). High FI expression was positively correlated with tumor size (p < 0.001), and Nottingham histological grade (p = 0.015) and associated with estrogen and progesterone receptor status (p = 0.03 and p = 0.009, respectively). Our data show that FI is expressed in breast cancer and is associated with unfavorable clinical outcome. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Holmquist, Emelieu Lund University,Lunds universitet,Proteinkemi, Malmö,Forskargrupper vid Lunds universitet,Protein Chemistry, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)med-ehi |
700 | 1 | a Nilsson, Eliseu Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)pat-eni |
700 | 1 | a Anagnostaki, Lola4 aut |
700 | 1 | a Jirström, Karinu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pat-kji |
700 | 1 | a Blom, Annau Lund University,Lunds universitet,Proteinkemi, Malmö,Forskargrupper vid Lunds universitet,Protein Chemistry, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)klke-abl |
710 | 2 | a Proteinkemi, Malmöb Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Cancer Immunology and Immunotherapyd : Springer Science and Business Media LLCg 64:4, s. 467-478q 64:4<467-478x 1432-0851x 0340-7004 |
856 | 4 | u https://portal.research.lu.se/files/1752053/7756498.pdfx primaryx freey FULLTEXT |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/25618258?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1007/s00262-015-1658-8y FULLTEXT |
856 | 4 | u https://lup.lub.lu.se/search/files/1752053/7756498.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/5039791 |
856 | 4 8 | u https://doi.org/10.1007/s00262-015-1658-8 |
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