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TERT promoter mutat...
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Killela, Patrick J.
(author)
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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2013-03-25
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Proceedings of the National Academy of Sciences,2013
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:ffecfaf3-3211-4e32-9008-8198f625fe5e
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https://lup.lub.lu.se/record/3851323URI
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https://doi.org/10.1073/pnas.1303607110DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Malignant cells, like all actively growing cells, must maintain their telomeres, but genetic mechanisms responsible for telomere maintenance in tumors have only recently been discovered. In particular, mutations of the telomere binding proteins alpha thalassemia/mental retardation syndrome X-linked (ATRX) or death-domain associated protein (DAXX) have been shown to underlie a telomere maintenance mechanism not involving telomerase (alternative lengthening of telomeres), and point mutations in the promoter of the telomerase reverse transcriptase (TERT) gene increase telomerase expression and have been shown to occur in melanomas and a small number of other tumors. To further define the tumor types in which this latter mechanism plays a role, we surveyed 1,230 tumors of 60 different types. We found that tumors could be divided into types with low (<15%) and high (>= 15%) frequencies of TERT promoter mutations. The nine TERT-high tumor types almost always originated in tissues with relatively low rates of self renewal, including melanomas, liposarcomas, hepatocellular carcinomas, urothelial carcinomas, squamous cell carcinomas of the tongue, medulloblastomas, and subtypes of gliomas (including 83% of primary glioblastoma, the most common brain tumor type). TERT and ATRX mutations were mutually exclusive, suggesting that these two genetic mechanisms confer equivalent selective growth advantages. In addition to their implications for understanding the relationship between telomeres and tumorigenesis, TERT mutations provide a biomarker that may be useful for the early detection of urinary tract and liver tumors and aid in the classification and prognostication of brain tumors.
Subject headings and genre
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Reitman, Zachary J.
(author)
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Jiao, Yuchen
(author)
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Bettegowda, Chetan
(author)
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Agrawal, Nishant
(author)
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Diaz Jr., Luis A.
(author)
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Friedman, Allan H.
(author)
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Friedman, Henry
(author)
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Gallia, Gary L.
(author)
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Giovanella, Beppino C.
(author)
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Grollman, Arthur P.
(author)
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He, Tong-Chuan
(author)
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He, Yiping
(author)
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Hruban, Ralph H.
(author)
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Jallo, George I.
(author)
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Mandahl, NilsLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)kgen-nma
(author)
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Meeker, Alan K.
(author)
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Mertens, FredrikLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)kgen-fme
(author)
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Netto, George J.
(author)
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Rasheed, B. Ahmed
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Riggins, Gregory J.
(author)
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Rosenquist, Thomas A.
(author)
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Schiffman, Mark
(author)
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Shih, Ie-Ming
(author)
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Theodorescu, Dan
(author)
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Torbenson, Michael S.
(author)
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Velculescu, Victor E.
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Wang, Tian-Li
(author)
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Wentzensen, Nicolas
(author)
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Wood, Laura D.
(author)
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Zhang, Ming
(author)
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McLendon, Roger E.
(author)
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Bigner, Darell D.
(author)
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Kinzler, Kenneth W.
(author)
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Vogelstein, Bert
(author)
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Papadopoulos, Nickolas
(author)
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Yan, Hai
(author)
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Avdelningen för klinisk genetikInstitutionen för laboratoriemedicin
(creator_code:org_t)
Related titles
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In:Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences110:15, s. 6021-60261091-64900027-8424
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Killela, Patrick ...
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Reitman, Zachary ...
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Jiao, Yuchen
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Bettegowda, Chet ...
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Agrawal, Nishant
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Diaz Jr., Luis A ...
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Friedman, Allan ...
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Friedman, Henry
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Gallia, Gary L.
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Giovanella, Bepp ...
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Grollman, Arthur ...
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He, Tong-Chuan
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He, Yiping
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Hruban, Ralph H.
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Jallo, George I.
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Mandahl, Nils
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Meeker, Alan K.
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Mertens, Fredrik
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Netto, George J.
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Rasheed, B. Ahme ...
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Riggins, Gregory ...
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Rosenquist, Thom ...
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Schiffman, Mark
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Shih, Ie-Ming
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Theodorescu, Dan
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Torbenson, Micha ...
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Velculescu, Vict ...
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Wang, Tian-Li
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Wentzensen, Nico ...
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Wood, Laura D.
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Zhang, Ming
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McLendon, Roger ...
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Bigner, Darell D ...
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Kinzler, Kenneth ...
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Vogelstein, Bert
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Papadopoulos, Ni ...
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Yan, Hai
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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Lund University