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Education level and...
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Brusselaers, NeleKarolinska Institutet
(author)
Education level and survival after esophageal cancer surgery : a prospective population-based cohort study
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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2013-12-03
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Stockholm :Karolinska Institutet, Dept of Molecular Medicine and Surgery,2013
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:openarchive.ki.se:10616/44565
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ISSN:2044-6055
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10616/44565hdl
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http://hdl.handle.net/10616/44565URI
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https://doi.org/10.1136/bmjopen-2013-003754DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:128238971URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-428684URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Objectives: This study aimed to investigate whether a higher education level is associated with an improved long-term survival after oesophagectomy for cancer. Design: A prospective, population-based cohort study. Setting: Sweden—nationwide. Participants: 90% of all patients with oesophageal and cardia cancer who underwent a resection in Sweden in 2001–2005 were enrolled in this study (N=600; 80.3% male) and followed up until death or the end of the study period (2012). The study exposure was level of education, defined as compulsory (≤9 years), moderate (10–12 years) or high (≥13 years). Outcome measures The main outcome measure was overall 5-year survival after oesophagectomy. Cox regression was used to estimate the associations between education level and mortality, expressed as HRs with 95% CIs, with adjustment for sex, age, tumour stage, histological type, complications, comorbidities and annual surgeon volume. The patient group with highest education was used as the reference category. Results: Among the 600 included patients, 281 (46.8%) had compulsory education, 238 (39.7%) had moderate education and 81 (13.5%) had high education. The overall 5-year survival rate was 23.1%, 24.4% and 32.1% among patients with compulsory, moderate and high education, respectively. After adjustment for confounders, a slightly higher, yet not statistically significantly increased point HR was found among the compulsory educated patients (HR 1.08, 95% CI 0.80 to 1.47). In patients with tumour stage IV, increased adjusted HRs were found for compulsory (HR 2.88, 95% CI 1.07 to 7.73) and moderately (HR 2.83, 95% CI 1.15 to 6.95) educated patients. No statistically significant associations were found for the other tumour stages. Conclusions: This study provides limited evidence of an association between lower education and worse long-term survival after oesophagectomy for cancer.
Added entries (persons, corporate bodies, meetings, titles ...)
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Ljung, RickardKarolinska Institutet
(author)
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Mattsson, FredrikKarolinska Institutet
(author)
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Johar, AsifKarolinska Institutet
(author)
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Wikman, AnnaKarolinska Institutet
(author)
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Lagergren, PernillaKarolinska Institutet
(author)
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Lagergren, JesperKarolinska Institutet
(author)
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Karolinska Institutet
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Karolinska Institutet
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:BMJ OpenStockholm : Karolinska Institutet, Dept of Molecular Medicine and Surgery2044-6055
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