Search: onr:"swepub:oai:openarchive.ki.se:10616/45317" > Common genetic vari...
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000 | 03546naa a2200505 4500 | |
001 | oai:openarchive.ki.se:10616/45317 | |
003 | SwePub | |
008 | 240410s2016 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:134559380 | |
022 | a 1949-2553 | |
024 | 7 | a 10616/453172 hdl |
024 | 7 | a http://hdl.handle.net/10616/453172 URI |
024 | 7 | a https://doi.org/10.18632/oncotarget.115752 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1345593802 URI |
040 | a (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Adel Fahmideh, Maralu Karolinska Institutet4 aut |
245 | 1 0 | a Common genetic variations in cell cycle and DNA repair pathways associated with pediatric brain tumor susceptibility |
264 | c 2016-08-24 | |
264 | 1 | a Stockholm :b Karolinska Institutet, Institute of Environmental Medicine,c 2016 |
338 | a electronic2 rdacarrier | |
520 | a Knowledge on the role of genetic polymorphisms in the etiology of pediatric brain tumors (PBTs) is limited. Therefore, we investigated the association between single nucleotide polymorphisms (SNPs), identified by candidate gene-association studies on adult brain tumors, and PBT risk. The study is based on the largest series of PBT cases to date. Saliva DNA from 245 cases and 489 controls, aged 7–19 years at diagnosis/reference date, was genotyped for 68 SNPs. Data were analyzed using unconditional logistic regression. The results showed EGFRrs730437 and EGFRrs11506105 may decrease susceptibility to PBTs, whereas ERCC1rs3212986 may increase risk of these tumors. Moreover, stratifid analyses indicated CHAF1Ars243341, CHAF1Ars2992, and XRCC1rs25487 were associated with a decreased risk of astrocytoma subtype. Furthermore, an increased risk of non-astrocytoma subtype associated with EGFRrs9642393, EME1rs12450550, ATMrs170548, and GLTSCRrs1035938 as well as a decreased risk of this subtype associated with XRCC4rs7721416 and XRCC4rs2662242 were detected. This study indicates SNPs in EGFR, ERCC1, CHAF1A, XRCC1, EME1, ATM, GLTSCR1, and XRCC4 may be associated with the risk of PBTs. Therefore, cell cycle and DNA repair pathways variations associated with susceptibility to adult brain tumors also seem to be associated with PBT risk, suggesting pediatric and adult brain tumors might share similar etiological pathways. | |
700 | 1 | a Lavebratt, Catharinau Karolinska Institutet4 aut |
700 | 1 | a Schüz, Joachim4 aut |
700 | 1 | a Röösli, Martin4 aut |
700 | 1 | a Tynes, Tore4 aut |
700 | 1 | a Grotzer, Michael A4 aut |
700 | 1 | a Johansen, Christoffer4 aut |
700 | 1 | a Kuehni, Claudia E4 aut |
700 | 1 | a Lannering, Birgitta4 aut |
700 | 1 | a Prochazka, Michaela4 aut |
700 | 1 | a Schmidt, Lisbeth S4 aut |
700 | 1 | a Feychting, Mariau Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutet |
710 | 2 | a Karolinska Institutet |
710 | 2 | a Karolinska Institutet4 org |
773 | 0 | t Oncotargetd Stockholm : Karolinska Institutet, Institute of Environmental Medicinex 1949-2553 |
856 | 4 | u http://hdl.handle.net/10616/45317x primaryx Object in contextx freey FULLTEXT |
856 | 4 | u http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=11575&path%5B%5D=36661 |
856 | 4 8 | u http://hdl.handle.net/10616/45317 |
856 | 4 8 | u https://doi.org/10.18632/oncotarget.11575 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:134559380 |
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