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A total-population ...
A total-population multigenerational family clustering study of autoimmune diseases in obsessive-compulsive disorder and Tourette’s/chronic tic disorders
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- Mataix-Cols, David (author)
- Karolinska Institutet
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- Frans, Emma (author)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Pérez-Vigil, Ana (author)
- Karolinska Institutet
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- Kuja-Halkola, Ralf (author)
- Karolinska Institutet
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- Gromark, Caroline (author)
- Karolinska Institutet
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- Isomura, Kayoko (author)
- Karolinska Institutet
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- Fernández de la Cruz, Lorena (author)
- Karolinska Institutet
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- Serlachius, Eva (author)
- Karolinska Institutet
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- Leckman, James F (author)
- Child Study Center, Yale University School of Medicine, New Haven CT, USA
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- Crowley, James J (author)
- Karolinska Institutet
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- Rück, Christian (author)
- Karolinska Institutet
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- Almqvist, Catarina (author)
- Karolinska Institutet
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- Lichtenstein, Paul (author)
- Karolinska Institutet
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- Larsson, Henrik, 1975- (author)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- ISSN 1359-4184
- 2017-11-14
- 2017
- English.
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In: Molecular Psychiatry. - Stockholm : Karolinska Institutet, Dept of Medical Epidemiology and Biostatistics. - 1359-4184 .- 1476-5578.
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https://europepmc.or...
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Abstract
Subject headings
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- The association between obsessive-compulsive disorder (OCD) and Tourette's/chronic tic disorders (TD/CTD) with autoimmune diseases (ADs) is uncertain. In this nationwide study, we sought to clarify the patterns of comorbidity and familial clustering of a broad range of ADs in individuals with OCD, individuals with TD/CTD and their biological relatives. From a birth cohort of 7 465 455 individuals born in Sweden between 1940 and 2007, we identified 30 082 OCD and 7279 TD/CTD cases in the National Patient Register and followed them up to 31 December 2013. The risk of 40 ADs was evaluated in individuals with OCD, individuals with TD/CTD and their first- (siblings, mothers, fathers), second- (half siblings) and third-degree (cousins) relatives, compared with population controls. Individuals with OCD and TD/CTD had increased comorbidity with any AD (43% and 36%, respectively) and many individual ADs. The risk of any AD and several individual ADs was consistently higher among first-degree relatives than among second- and third-degree relatives of OCD and TD/CTD probands. The risk of ADs was very similar in mothers, fathers and siblings of OCD probands, whereas it tended to be higher in mothers and fathers of TD/CTD probands (compared with siblings). The results suggest a familial link between ADs in general (that is, not limited to Streptococcus-related conditions) and both OCD and TD/CTD. Additional mother-specific factors, such as the placental transmission of antibodies, cannot be fully ruled out, particularly in TD/CTD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Mataix-Cols, Dav ...
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Frans, Emma
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Pérez-Vigil, Ana
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Kuja-Halkola, Ra ...
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Gromark, Carolin ...
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Isomura, Kayoko
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show more...
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Fernández de la ...
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Serlachius, Eva
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Leckman, James F
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Crowley, James J
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Rück, Christian
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Almqvist, Catari ...
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Lichtenstein, Pa ...
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Larsson, Henrik, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Molecular Psychi ...
- By the university
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Karolinska Institutet
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Örebro University