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Deregulation of cyc...
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Ekholm-Reed, S
(författare)
Deregulation of cyclin E in human cells interferes with prereplication complex assembly
- Artikel/kapitelEngelska2004
Förlag, utgivningsår, omfång ...
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2004-06-14
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Rockefeller University Press,2004
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:110280230
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http://kipublications.ki.se/Default.aspx?queryparsed=id:110280230URI
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https://doi.org/10.1083/jcb.200404092DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Deregulation of cyclin E expression has been associated with a broad spectrum of human malignancies. Analysis of DNA replication in cells constitutively expressing cyclin E at levels similar to those observed in a subset of tumor-derived cell lines indicates that initiation of replication and possibly fork movement are severely impaired. Such cells show a specific defect in loading of initiator proteins Mcm4, Mcm7, and to a lesser degree, Mcm2 onto chromatin during telophase and early G1 when Mcm2–7 are normally recruited to license origins of replication. Because minichromosome maintenance complex proteins are thought to function as a heterohexamer, loading of Mcm2-, Mcm4-, and Mcm7-depleted complexes is likely to underlie the S phase defects observed in cyclin E–deregulated cells, consistent with a role for minichromosome maintenance complex proteins in initiation of replication and fork movement. Cyclin E–mediated impairment of DNA replication provides a potential mechanism for chromosome instability observed as a consequence of cyclin E deregulation.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Mendez, J
(författare)
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Tedesco, D
(författare)
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Zetterberg, AKarolinska Institutet
(författare)
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Stillman, B
(författare)
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Reed, SI
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:The Journal of cell biology: Rockefeller University Press165:6, s. 789-8000021-95251540-8140
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