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Are Parkinson's dis...
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Aarsland, DKarolinska Institutet
(author)
Are Parkinson's disease with dementia and dementia with Lewy bodies the same entity?
- Article/chapterEnglish2004
Publisher, publication year, extent ...
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2004-08-05
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SAGE Publications,2004
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:110467071
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http://kipublications.ki.se/Default.aspx?queryparsed=id:110467071URI
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https://doi.org/10.1177/0891988704267470DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The diagnosis of Parkinson’s disease with dementia (PDD) or dementia with Lewy bodies (DLB) is based on an arbitary distinction between the time of onset of motor and cognitive symptoms. These syndromes share many neurobiological similarities, but there are also differences. Deposition of beta-amyloid protein is more marked and more closely related to cognitive impairment in DLB than PDD, possibly contributing to dementia at onset. The relatively more severe executive impairment in DLB than PDD may relate to the loss of frontohippocampal projections in DLB. Visual hallucinations and delusions associate with more abundant Lewy body pathology in temporal cortex in DLB. The differential involvement of pathology in the striatum may account for the differences in parkinsonism. Longitudinal studies with neuropathological and neurochemical evaluations will be essential to enable more robust comparisons and determine pathological substrates contributing to the differences in cognitive, motor, and psychiatric symptoms. ( J Geriatr Psychiatry Neurol 2004; 17:137-145)
Added entries (persons, corporate bodies, meetings, titles ...)
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Ballard, CG
(author)
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Halliday, G
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Journal of geriatric psychiatry and neurology: SAGE Publications17:3, s. 137-1450891-98871552-5708
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