The effect of apolipoprotein polymorphism on brain in mild cognitive impairment: a voxel-based morphometric study

Pennanen, C (author)

Testa, C (author)

Boccardi, M (author)

Laakso, MP (author)

Hallikainen, M (author)

Helkala, EL (author)

Hanninen, T (author)

Kononen, M (author)

Nissinen, A (author)

Tervo, S (author)

Vanhanen, M (author)

Vanninen, R (author)

Frisoni, GB (author)

Soininen, H (author)

(creator_code:org_t)

2006-06-19
2006
English.
In: Dementia and geriatric cognitive disorders. - : S. Karger AG. - 1420-8008 .- 1421-9824. ; 22:1, s. 60-66

Related links:: http://kipublication...; show more...; https://doi.org/10.1...; show less...

Abstract Subject headings

We investigated the effect of apolipoprotein E (ApoE) on the whole brain in 51 individuals with mild cognitive impairment using voxel-based morphometry. Between cases heterozygous for the ApoE Ε4 (n = 15) and those who were ApoE Ε4 noncarriers (n = 28), only the right parahippocampal gyrus, with the entorhinal cortex included, reached the level of statistical significance. In cases homozygous for the Ε4 allele (n = 8) versus noncarriers, the greatest atrophy was located in the right amygdala followed by the right parahippocampal gyrus, the left amygdala and the left medial dorsal thalamic nucleus.

By the author/editor: Pennanen, C; Testa, C; Boccardi, M; Laakso, MP; Hallikainen, M; Helkala, EL; show more...; Hanninen, T; Kivipelto, M; Kononen, M; Nissinen, A; Tervo, S; Vanhanen, M; Vanninen, R; Frisoni, GB; Soininen, H; show less...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.