Search: onr:"swepub:oai:prod.swepub.kib.ki.se:113279116" >
The site of action ...
The site of action of neuronal acidic fibroblast growth factor is the organ of Corti of the rat cochlea
- Article/chapterEnglish1995
Publisher, publication year, extent ...
-
1995-09-26
-
Proceedings of the National Academy of Sciences,1995
Numbers
-
LIBRIS-ID:oai:prod.swepub.kib.ki.se:113279116
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:113279116URI
-
https://doi.org/10.1073/pnas.92.20.9269DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Here we show that the mature cochlear neurons are a rich source of acidic fibroblast growth factor (aFGF), which is expressed in the neuronal circuitry consisting of afferent and efferent innervation. The site of action of neuronal aFGF is likely to reside in the organ of Corti, where one of the four known FGF receptor (FGFR) tyrosine kinases--namely, FGFR-3 mRNA--is expressed. Following acoustic overstimulation, known to cause damage to the organ of Corti, a rapid up-regulation of FGFR-3 is evident in this sensory epithelium, at both mRNA and protein levels. The present results provide in vivo evidence for aFGF being a sensory neuron-derived, anterogradely transported factor that may exert trophic effects on a peripheral target tissue. In this sensory system, aFGF, rather than being a neurotrophic factor, seems to promote maintenance of the integrity of the organ of Corti. In addition, aFGF, released from the traumatized nerve endings, may be one of the first signals initiating protective recovery and repair processes following damaging auditory stimuli.
Added entries (persons, corporate bodies, meetings, titles ...)
-
CAO, YHKarolinska Institutet
(author)
-
OELLIG, C
(author)
-
ZHAI, SQ
(author)
-
PETTERSSON, RF
(author)
-
YLIKOSKI, J
(author)
-
Karolinska Institutet
(creator_code:org_t)
Related titles
-
In:Proceedings of the National Academy of Sciences of the United States of America: Proceedings of the National Academy of Sciences92:20, s. 9269-92730027-8424
-
In:Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences92:20, s. 9269-92731091-6490
Internet link
Find in a library
To the university's database