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Keratinocyte growth...
Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques
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Seggewiss, R (author)
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- Lore, K (author)
- Karolinska Institutet
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Guenaga, FJ (author)
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Pittaluga, S (author)
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Mattapallil, J (author)
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Chow, CK (author)
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Koup, RA (author)
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Camphausen, K (author)
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Nason, MC (author)
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Meier-Schellersheim, M (author)
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Donahue, RE (author)
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Blazar, BR (author)
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Dunbar, CE (author)
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Douek, DC (author)
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(creator_code:org_t)
- American Society of Hematology, 2007
- 2007
- English.
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In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 110:1, s. 441-449
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https://europepmc.or...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Opportunistic infections contribute to morbidity and mortality after peripheral blood progenitor cell (PBPC) transplantation and are related to a deficient T-cell compartment. Accelerated T-cell reconstitution may therefore be clinically beneficent. Keratinocyte growth factor (KGF) has been shown to protect thymic epithelial cells in mice. Here, we evaluated immune reconstitution after autologous CD34+ PBPC transplantation in rhesus macaques conditioned with myeloablative total body irradiation in the absence or presence of single pretotal body irradiation or repeated peritransplant KGF administration. All KGF-treated animals exhibited a well-preserved thymic architecture 12 months after graft. In contrast, thymic atrophy was observed in the majority of animals in the control group. The KGF-treated animals showed higher frequencies of naive T cells in lymph nodes after transplantation compared with the control animals. The animals given repeated doses of KGF showed the highest levels of T-cell receptor excision circles (TRECs) and the lowest frequencies of Ki67+ T cells, which suggest increased thymic-dependent reconstitution in these animals. Of note, the humoral response to a T-cell–dependent neo-antigen was significantly higher in the KGF-treated animals compared with the control animals. Thus, our findings suggest that KGF may be a useful adjuvant therapy to augment T-cell reconstitution after human PBPC transplantation.
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- art (subject category)
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Blood
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- By the author/editor
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Seggewiss, R
-
Lore, K
-
Guenaga, FJ
-
Pittaluga, S
-
Mattapallil, J
-
Chow, CK
-
show more...
-
Koup, RA
-
Camphausen, K
-
Nason, MC
-
Meier-Schellersh ...
-
Donahue, RE
-
Blazar, BR
-
Dunbar, CE
-
Douek, DC
-
show less...
- Articles in the publication
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Blood
- By the university
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Karolinska Institutet