Search: onr:"swepub:oai:prod.swepub.kib.ki.se:115752741" >
Combinatorial prote...
Combinatorial protein therapy of angiogenic and arteriogenic factors remarkably improves collaterogenesis and cardiac function in pigs
-
Lu, HX (author)
-
Xu, XS (author)
-
Zhang, M (author)
-
show more...
-
- Cao, RH (author)
- Karolinska Institutet
-
Brakenhielm, E (author)
-
Li, CJ (author)
-
Lin, HL (author)
-
Yao, GH (author)
-
Sun, HW (author)
-
Qi, LH (author)
-
Tang, MX (author)
-
Dai, HY (author)
-
Zhang, Y (author)
-
Su, R (author)
-
Bi, YW (author)
-
Zhang, Y (author)
-
- Cao, YH (author)
- Karolinska Institutet
-
show less...
-
(creator_code:org_t)
- 2007-07-17
- 2007
- English.
-
In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 104:29, s. 12140-12145
- Related links:
-
https://www.pnas.org...
-
show more...
-
http://kipublication...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Establishment of functional and stable collaterals in the ischemic myocardium is crucial to restoring cardiac function after myocardial infarction. Here, we show that only dual delivery of a combination of angiogenic and arteriogenic factors to the ischemic myocardium could significantly reestablish stable collateral networks and improve myocardial perfusion and function. A combination of FGF-2 with PDGF-BB, two factors primarily targeting endothelial cells and vascular smooth muscle cells, remarkably promotes myocardial collateral growth and stabilizes the newly formed collateral networks, which significantly restore myocardial perfusion and function. Using various members of the PDGF family together with FGF-2 in an angiogenesis assay, we demonstrate that PDGFR-α is mainly involved in angiogenic synergism, whereas PDGFR-β mediates vessel stability signals. Our findings provide conceptual guidelines for the clinical development of proangiogenic/arteriogenic factors for the treatment of ischemic heart disease.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Lu, HX
-
Xu, XS
-
Zhang, M
-
Cao, RH
-
Brakenhielm, E
-
Li, CJ
-
show more...
-
Lin, HL
-
Yao, GH
-
Sun, HW
-
Qi, LH
-
Tang, MX
-
Dai, HY
-
Zhang, Y
-
Su, R
-
Bi, YW
-
Cao, YH
-
show less...
- Articles in the publication
-
Proceedings of t ...
-
Proceedings of t ...
- By the university
-
Karolinska Institutet